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早期补饲和断奶对新生仔猪血浆代谢组产后演变的影响。

Creep Feeding and Weaning Influence the Postnatal Evolution of the Plasma Metabolome in Neonatal Piglets.

作者信息

Metzler-Zebeli Barbara U, Lerch Frederike, Yosi Fitra, Vötterl Julia C, Koger Simone, Aigensberger Markus, Rennhofer Patrick M, Berthiller Franz, Schwartz-Zimmermann Heidi E

机构信息

Unit of Nutritional Physiology, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Christian-Doppler Laboratory for Innovative Gut Health Concepts of Livestock, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

出版信息

Metabolites. 2023 Jan 31;13(2):214. doi: 10.3390/metabo13020214.

DOI:10.3390/metabo13020214
PMID:36837833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9960666/
Abstract

Data on the evolution of blood metabolites and metabolic markers in neonatal piglets are scarce, although this information is vital to detect physiological aberrations from normal development. We aimed to characterize age- and nutrition-related changes in the plasma metabolome and serum biochemistry of suckling and newly weaned piglets and assess metabolite patterns as physiological markers for the two phases. In two replicate batches ( = 10 litters/group), piglets either received sow milk alone or were additionally offered creep feed from day 10 until weaning (day 28). Blood was collected from one piglet/litter on days 7, 14, 21, 28, 31 and 35 of life, totaling five females and five males/group/day. Signature feature ranking identified plasma triglycerides (TG) as discriminative for age and nutrition during the suckling phase. Influential TG 20:4_36:5, TG 17:0_34:2 and TG 18:2_38:6 were higher in creep-fed piglets on days 14, 21 and 28 of life, respectively, compared to only sow milk-fed piglets. Metabolites belonging to pathways within histidine, D-glutamine and D-glutamate metabolism as well as hippuric acid were distinctive for the postweaning compared to the suckling period. In conclusion, plasma lipid profiles especially corresponded to the type of nutrition in the suckling phase and showed a strong weaning effect.

摘要

关于新生仔猪血液代谢物和代谢标志物演变的数据很少，尽管这些信息对于检测正常发育过程中的生理异常至关重要。我们旨在描述哺乳仔猪和刚断奶仔猪血浆代谢组和血清生化指标中与年龄和营养相关的变化，并评估代谢物模式作为这两个阶段的生理标志物。在两个重复批次中（每组 = 10窝），仔猪要么仅接受母乳，要么从第10天开始额外提供开食料直至断奶（第28天）。在仔猪出生后的第7、14、21、28、31和35天，从每窝中采集一头仔猪的血液，每组每天共采集5只雌性和5只雄性仔猪的血液。特征排序确定血浆甘油三酯（TG）是哺乳阶段年龄和营养的判别指标。在出生后的第14、21和28天，与仅喂母乳的仔猪相比，补饲开食料的仔猪中具有影响力的TG 20:4_36:5、TG 17:0_34:2和TG 18:2_38:6分别更高。与哺乳期相比，断奶后属于组氨酸、D - 谷氨酰胺和D - 谷氨酸代谢途径以及马尿酸的代谢物具有独特性。总之，血浆脂质谱尤其与哺乳阶段的营养类型相对应，并显示出强烈的断奶效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/554f56576fe8/metabolites-13-00214-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/825d5d0214ba/metabolites-13-00214-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/554f56576fe8/metabolites-13-00214-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/e8eca6a8a36e/metabolites-13-00214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/fbb020d85aaf/metabolites-13-00214-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/579a/9960666/554f56576fe8/metabolites-13-00214-g007.jpg

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