唾液代谢组学在神经退行性痴呆诊断与监测中的应用

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia.

作者信息

Hyvärinen Eelis, Solje Eino, Vepsäläinen Jouko, Kullaa Arja, Tynkkynen Tuulia

机构信息

Institute of Dentistry, University of Eastern Finland, 70210 Kuopio, Finland.

Institute of Clinical Medicine, Neurology, University of Eastern Finland, 70210 Kuopio, Finland.

出版信息

Metabolites. 2023 Feb 4;13(2):233. doi: 10.3390/metabo13020233.

DOI:10.3390/metabo13020233

PMID:36837852

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9968225/

Abstract

Millions of people suffer with dementia worldwide. However, early diagnosis of neurodegenerative diseases/dementia (NDD) is difficult, and no specific biomarkers have been found. This study aims to review the applications of salivary metabolomics in diagnostics and the treatment monitoring of NDD A literature search of suitable studies was executed so that a total of 29 original research articles were included in the present review. Spectroscopic methods, mainly nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, give us a broad view of changes in salivary metabolites in neurodegenerative diseases. The role of different salivary metabolites in brain function is discussed. Further studies with larger patient cohorts should be carried out to investigate the association between salivary metabolites and brain function and thus learn more about the complicated pathways in the human body.

摘要

全球数以百万计的人患有痴呆症。然而，神经退行性疾病/痴呆症（NDD）的早期诊断很困难，并且尚未发现特定的生物标志物。本研究旨在综述唾液代谢组学在NDD诊断和治疗监测中的应用。我们进行了合适研究的文献检索，以便本综述共纳入29篇原创研究文章。光谱学方法，主要是核磁共振（NMR）光谱和质谱，让我们对神经退行性疾病中唾液代谢物的变化有了广泛的了解。文中讨论了不同唾液代谢物在脑功能中的作用。应该开展更大患者队列的进一步研究，以调查唾液代谢物与脑功能之间的关联，从而更多地了解人体中复杂的通路。