Braun S R, Sufit R L, Giovannoni R, O'Connor M, Peters H
Department of Medicine, University of Missouri, Columbia 65212.
Neurology. 1987 Dec;37(12):1874-5. doi: 10.1212/wnl.37.12.1874.
Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully treated with NPV alone. This patient and two other ALS patients in chronic respiratory failure with PaCO2 elevation stabilized or improved their vital capacity (VC) and lowered their PaCO2 after 5 to 11 weeks of therapy. Finally, intermittent NPV was used to replace 24-hour positive pressure ventilation in two patients with DMD. It is concluded that intermittent NPV may stabilize or temporarily improve the respiratory status in patients with progressive neuromuscular diseases.
五名患有退行性神经肌肉疾病（三名患有肌萎缩侧索硬化症[ALS]，两名患有杜氏肌营养不良症[DMD]）且出现呼吸衰竭的男性接受了间歇性负压通气（NPV）治疗。一名患有严重急性呼吸衰竭的ALS患者仅通过NPV就得到了成功治疗。该患者以及另外两名患有慢性呼吸衰竭且伴有PaCO2升高的ALS患者在接受5至11周治疗后，肺活量（VC）稳定或改善，PaCO2降低。最后，间歇性NPV被用于替代两名DMD患者的24小时正压通气。结论是，间歇性NPV可能会稳定或暂时改善进行性神经肌肉疾病患者的呼吸状况。
