Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea.
Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Republic of Korea.
Nutrients. 2023 Feb 13;15(4):936. doi: 10.3390/nu15040936.
The longitudinal effect of B12 insufficiency on sarcopenia has not yet been investigated in older adults. We aimed to study the impact of B12 levels on alterations in muscle mass, function and strength over two years. Non-sarcopenic older adults ( = 926) aged 70-84 were included. Using the Korean Frailty and Aging Cohort Study, this two-year longitudinal study used data across South Korea. The tools used for assessing muscle criteria were based on the Asian Working Group for Sarcopenia guidelines. Participants were divided into the insufficiency (initial serum B12 concentration < 350 pg/mL) and sufficiency groups (≥350 pg/mL). Logistic regression analyses were performed to evaluate the effect of initial B12 concentration on sarcopenia parameters over a two-year period. In women, multivariate analysis showed that the B12 insufficiency group had a significantly higher incidence of low SPPB scores (odds ratio [OR] = 3.28, 95% confidence interval [CI] = 1.59-6.76) and sarcopenia (OR = 3.72, 95% CI = 1.10-12.62). However, the B12 insufficiency group did not have a greater incidence of sarcopenia or other parameters in men. Our findings suggest B12 insufficiency negatively impacts physical performance and increases the incidence of sarcopenia only in women.
在老年人中，尚未研究 B12 不足对肌肉减少症的纵向影响。我们旨在研究 B12 水平对两年内肌肉质量、功能和力量变化的影响。纳入了年龄在 70-84 岁的非肌肉减少症老年人（n=926）。这项为期两年的纵向研究使用了来自韩国的韩国衰弱和衰老队列研究的数据。评估肌肉标准的工具基于亚洲肌肉减少症工作组的指南。参与者分为不足组（初始血清 B12 浓度<350 pg/mL）和充足组（≥350 pg/mL）。采用逻辑回归分析评估初始 B12 浓度对两年内肌肉减少症参数的影响。在女性中，多变量分析显示，B12 不足组的 SPPB 评分较低的发生率显著更高（比值比 [OR] = 3.28，95%置信区间 [CI] = 1.59-6.76）和肌肉减少症（OR = 3.72，95% CI = 1.10-12.62）。然而，B12 不足组在男性中肌肉减少症或其他参数的发生率没有更高。我们的研究结果表明，B12 不足会对身体机能产生负面影响，仅在女性中增加肌肉减少症的发生率。
