Department of Sports Teaching, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Department of Healthcare Information and Management, School of Health Technology, Ming Chuan University, Taoyuan, Taiwan.
Medicine (Baltimore). 2023 Dec 15;102(50):e36517. doi: 10.1097/MD.0000000000036517.
Sarcopenia increases disability, hospital stays, readmissions, and mortality in older adults. Antioxidative nutrients and fatty acids consumption may help maintain muscle mass by reducing oxidative stress. This study aims to assess the association between antioxidant and fatty acid intake and low muscle mass in community-dwelling older people. This retrospective analysis used data from the National Health and Nutrition Examination Survey from 1999 to 2004. Participants ≥ 60 years with information on muscle mass measured by Dual energy X-ray absorptiometry (DXA) were included. Appendicular skeletal muscle mass was assessed. Associations between antioxidants and fatty acids intake, and low muscle mass were evaluated using logistic regressions. 3648 (1748 men and 1900 women) were included. The prevalence of low muscle mass was 41% and 26% among men and women ≥ 75 years, and 45.2% and 28.4% among obese men and women. In obese males, a natural-log-unit increase of vitamin A (aOR = 0.806, 95% CI: 0.652-0.996), vitamin C (aOR = 0.878, 95% CI: 0.779-0.990), selenium intake (aOR = 0.716, 95% CI: 0.517-0.993), and higher saturated fatty acids (aOR = 0.956, 95% CI: 0.915-0.998) and monounsaturated fatty acids (aOR = 0.959, 95% CI: 0.925-0.994) intake were associated with decreased odds for low muscle mass. Among obese females, a natural-log-unit increase of vitamin E (P = .036), vitamin B12 (P = .014), total folate (P = .015), zinc (P = .005), and selenium intake (P = .018) were associated with increased odds of low muscle mass, whereas higher saturated fatty acids (P < .001), monounsaturated fatty acids (P = .001), and polyunsaturated fatty acids intake (P = .006) were associated with decreased odds for low muscle mass. Antioxidants (vitamin A, C, E, B6, B12, total folate, zinc, magnesium, selenium) intake does not consistently relate to low muscle mass across age and sex. Higher intake of saturated, monounsaturated, and polyunsaturated fatty acids are independently associated with reduced likelihood of low muscle mass in both obese older men and women.
肌少症会增加老年人的残疾、住院、再入院和死亡率。抗氧化营养素和脂肪酸的摄入可能通过减少氧化应激来帮助维持肌肉质量。本研究旨在评估社区居住的老年人的抗氧化剂和脂肪酸摄入与低肌肉量之间的关联。本回顾性分析使用了 1999 年至 2004 年全国健康和营养检查调查的数据。纳入了信息来自双能 X 射线吸收法（DXA）测量的肌肉量的参与者≥60 岁。评估了四肢骨骼肌质量。使用逻辑回归评估抗氧化剂和脂肪酸摄入与低肌肉量之间的关联。纳入了 3648 名（1748 名男性和 1900 名女性）参与者。≥75 岁的男性和女性的低肌肉量患病率分别为 41%和 26%，肥胖男性和女性的低肌肉量患病率分别为 45.2%和 28.4%。在肥胖男性中，维生素 A（aOR=0.806，95%CI：0.652-0.996）、维生素 C（aOR=0.878，95%CI：0.779-0.990）、硒摄入量（aOR=0.716，95%CI：0.517-0.993）和更高的饱和脂肪酸（aOR=0.956，95%CI：0.915-0.998）和单不饱和脂肪酸（aOR=0.959，95%CI：0.925-0.994）的天然对数单位增加与低肌肉量的几率降低有关。在肥胖女性中，维生素 E（P=0.036）、维生素 B12（P=0.014）、总叶酸（P=0.015）、锌（P=0.005）和硒摄入量（P=0.018）的天然对数单位增加与低肌肉量的几率增加有关，而饱和脂肪酸（P<0.001）、单不饱和脂肪酸（P=0.001）和多不饱和脂肪酸（P=0.006）的摄入量增加与低肌肉量的几率降低有关。抗氧化剂（维生素 A、C、E、B6、B12、总叶酸、锌、镁、硒）的摄入并不能在不同年龄和性别之间始终与低肌肉量相关。较高的饱和、单不饱和和多不饱和脂肪酸摄入量与肥胖的老年男性和女性的低肌肉量发生几率降低独立相关。
