Kobryń Justyna, Raszewski Bartosz, Zięba Tomasz, Musiał Witold
Department and Chair of Physical Chemistry and Biophysics, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland.
Department of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland.
Pharmaceutics. 2023 Jan 23;15(2):387. doi: 10.3390/pharmaceutics15020387.
The problem of drug delivery often concentrates on the prolongation of drug activity. Application of natural polymers which are biodegradable and inexpensive is in the interest of many researchers. The aim of this study was the application of newly synthesized starch derivatives as potential functional excipients proposed for hydrophilic gel with lidocaine hydrochloride (LH) to prolong drug release from the hydrogel matrix. In our study, we investigated the effect of starch modified with citric acid on the release kinetics of LH using UV-VIS and Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), as well as viscosity and pH measurements. We demonstrated the effectiveness of citric-acid-modified starch in prolonging the release of LH from methylcellulose gel.
药物递送问题通常集中在延长药物活性上。应用可生物降解且价格低廉的天然聚合物受到许多研究人员的关注。本研究的目的是将新合成的淀粉衍生物用作潜在的功能性辅料，用于含盐酸利多卡因（LH）的亲水性凝胶，以延长药物从水凝胶基质中的释放。在我们的研究中，我们使用紫外可见光谱和傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）以及粘度和pH测量，研究了柠檬酸改性淀粉对LH释放动力学的影响。我们证明了柠檬酸改性淀粉在延长LH从甲基纤维素凝胶中释放方面的有效性。
