Sun Jiayi, Zhang Zhen, Fei Yunhan, Gao Yannan, Li Zejian, Gao Shuai, Wang Yunfan, Liu Jie, Tu Jun, Wang Haiying, Wang Jinghua, Ning Xianjia, Zhao Wenjuan, Zhang Wenjuan
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Emergency, Tianjin Huanhu Hospital, Tianjin, China.
Front Cardiovasc Med. 2023 Feb 9;10:1037227. doi: 10.3389/fcvm.2023.1037227. eCollection 2023.
Arterial stiffness is closely associated with the occurrence of many cardiovascular and cerebrovascular diseases. However, the risk factors and mechanisms related to arterial stiffness development have only been partially elucidated. We aimed to describe arterial elastic function and its influencing factors in middle-aged and elderly people in rural China.
This was a cross-sectional study conducted among residents, aged ≥45 years, of Tianjin, China, between April and July 2015. Data regarding participant demographics, medical history, lifestyle, and physical examination results were collected and assessed the association with arterial elastic function using linear regression.
Of the 3,519 participants, 1,457 were male (41.4%). Brachial artery distensibility (BAD) decreased by 0.5%/mmHg with every 10-year increment in age. The mean BAD value was 0.864%/mmHg lower in women than in men. With each unit increase in mean arterial pressure, the BAD decreased by 0.042%/mmHg. In patients with hypertension or diabetes, the BAD decreased by 0.726 and 0.183%/mmHg, respectively, compared with those without hypertension or diabetes. For each unit increase in triglyceride (TG) level, the mean BAD increased by 0.043%/mmHg. With each increase in body mass index (BMI) category, the BAD increased by 0.113%/mmHg. Brachial artery compliance (BAC) decreased by 0.007 ml/mmHg with each 10-year increase in age, and brachial artery resistance (BAR) increased by 30.237 dyn s cm. The mean BAC in women was 0.036 ml/mmHg lower and the mean BAR was 155.231 dyn s cm higher in women than in men. In individuals with hypertension, the mean BAC decreased by 0.009 ml/mmHg and the mean BAR increased by 26.169 dyn s cm. With each increase in BMI category, the mean BAC increased by 0.005 ml/mmHg and the mean BAR decreased by 31.345 dyn s cm. For each unit increase in TG level, the mean BAC increased by 0.001 ml/mmHg.
These findings indicate that age, sex, mean arterial pressure, BMI, diabetes, hypertension, and TG level are independently associated with the components of peripheral arterial elasticity. Understanding the factors influencing arterial stiffness is important for developing interventions to minimize arterial aging and cardiovascular and cerebrovascular diseases caused by arterial aging.
动脉僵硬度与许多心脑血管疾病的发生密切相关。然而，与动脉僵硬度发展相关的危险因素和机制仅得到部分阐明。我们旨在描述中国农村中老年人的动脉弹性功能及其影响因素。
这是一项于2015年4月至7月在中国天津对年龄≥45岁的居民进行的横断面研究。收集了参与者的人口统计学、病史、生活方式和体格检查结果等数据，并使用线性回归评估其与动脉弹性功能的关联。
在3519名参与者中，1457名是男性（41.4%）。肱动脉扩张性（BAD）随年龄每增加10岁下降0.5%/mmHg。女性的平均BAD值比男性低0.864%/mmHg。平均动脉压每升高一个单位，BAD下降0.042%/mmHg。与无高血压或糖尿病的患者相比，高血压或糖尿病患者的BAD分别下降0.726和0.183%/mmHg。甘油三酯（TG）水平每升高一个单位，平均BAD升高0.043%/mmHg。体重指数（BMI）类别每增加一级，BAD升高0.113%/mmHg。肱动脉顺应性（BAC）随年龄每增加10岁下降0.007 ml/mmHg，肱动脉阻力（BAR）增加30.237 dyn s cm。女性的平均BAC比男性低0.036 ml/mmHg，平均BAR比男性高155.231 dyn s cm。在高血压患者中，平均BAC下降0.009 ml/mmHg，平均BAR增加26.169 dyn s cm。BMI类别每增加一级，平均BAC增加0.005 ml/mmHg，平均BAR下降31.345 dyn s cm。TG水平每升高一个单位，平均BAC增加0.001 ml/mmHg。
这些发现表明，年龄、性别、平均动脉压、BMI、糖尿病、高血压和TG水平与外周动脉弹性成分独立相关。了解影响动脉僵硬度的因素对于制定干预措施以尽量减少动脉老化以及由动脉老化引起的心脑血管疾病至关重要。
