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通过SIRT信号通路改善卵母细胞质量。

Improvement of oocyte quality through the SIRT signaling pathway.

作者信息

Vo Kim Cat Tuyen, Sato Yorino, Kawamura Kazuhiro

机构信息

Graduate School of Medicine International University of Health and Welfare School of Medicine Narita-shi Japan.

Department of Obstetrics & Gynaecology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam.

出版信息

Reprod Med Biol. 2023 Feb 23;22(1):e12510. doi: 10.1002/rmb2.12510. eCollection 2023 Jan-Dec.

DOI:10.1002/rmb2.12510
PMID:36845003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9949364/
Abstract

BACKGROUND

Oocyte quality is one of the major deciding factors in female fertility competence.

METHODS

PubMed database was searched for reviews by using the following keyword "oocyte quality" AND "Sirtuins". The methodological quality of each literature review was assessed using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement.

MAIN FINDINGS

Oxidative stress has been recognized as the mechanism attenuating oocyte quality. Increasing evidence from animal experiments and clinical studies has confirmed the protective roles of the sirtuin family in improving oocyte quality via an antioxidant effect.

CONCLUSION

The protective roles in the oocyte quality of the sirtuin family have been increasingly recognized.

摘要

背景

卵母细胞质量是女性生育能力的主要决定因素之一。

方法

使用关键词“卵母细胞质量”和“沉默调节蛋白”在PubMed数据库中检索综述。采用系统评价和Meta分析的首选报告项目（PRISMA）2020声明评估每篇文献综述的方法学质量。

主要发现

氧化应激已被确认为削弱卵母细胞质量的机制。来自动物实验和临床研究的越来越多的证据证实了沉默调节蛋白家族通过抗氧化作用在改善卵母细胞质量方面的保护作用。

结论

沉默调节蛋白家族在卵母细胞质量方面的保护作用已得到越来越多的认可。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/f811abe9830b/RMB2-22-e12510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/b6a9f87d2b31/RMB2-22-e12510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/3d030fe15ee9/RMB2-22-e12510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/f811abe9830b/RMB2-22-e12510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/b6a9f87d2b31/RMB2-22-e12510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/3d030fe15ee9/RMB2-22-e12510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1134/9949364/f811abe9830b/RMB2-22-e12510-g001.jpg

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Aging (Albany NY). 2022 Jul 8;14(14):5628-5640. doi: 10.18632/aging.204157.
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Protective effects of a SIRT1 inhibitor on primordial follicle activation and growth induced by cyclophosphamide: insights from a bovine in vitro folliculogenesis system.
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Epigenetics. 2025 Dec;20(1):2528563. doi: 10.1080/15592294.2025.2528563. Epub 2025 Jul 7.
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