Reilly Matthew A, Katz Steven E, Roberts Cynthia J
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, United States.
Front Bioeng Biotechnol. 2023 Feb 9;11:1095948. doi: 10.3389/fbioe.2023.1095948. eCollection 2023.
Spaceflight-Associated Neuro-ocular Syndrome (SANS) is a descriptor of several ocular and visual signs and symptoms which commonly afflicts those exposed to microgravity. We propose a new theory for the driving force leading to the development of Spaceflight-Associated Neuro-ocular Syndrome which is described a finite element model of the eye and orbit. Our simulations suggest that the anteriorly directed force produced by orbital fat swelling is a unifying explanatory mechanism for Spaceflight-Associated Neuro-ocular Syndrome, as well as producing a larger effect than that generated by elevation in intracranial pressure. Hallmarks of this new theory include broad flattening of the posterior globe, loss of tension in the peripapillary choroid, decreased axial length, consistent with findings in astronauts. A geometric sensitivity study suggests several anatomical dimensions may be protective against Spaceflight-Associated Neuro-ocular Syndrome.
航天相关神经眼科综合征（SANS）是描述几种眼部和视觉体征及症状的术语，这些症状通常困扰着暴露于微重力环境的人。我们提出了一种导致航天相关神经眼科综合征发展的驱动力新理论，该理论由眼睛和眼眶的有限元模型描述。我们的模拟表明，眼眶脂肪肿胀产生的向前作用力是航天相关神经眼科综合征的统一解释机制，并且比颅内压升高产生的影响更大。这一新理论的特征包括眼球后部广泛扁平、视乳头周围脉络膜张力丧失、眼轴长度缩短，与宇航员的发现一致。一项几何敏感性研究表明，几个解剖学维度可能对航天相关神经眼科综合征具有保护作用。
