Salimian Sina, Habibi Maryam, Sehat Mojtaba, Hajian Abbas
Department of Internal Medicine, Faculty of Medicine.
Autoimmune Disease Research Center.
Ann Med Surg (Lond). 2023 Feb 6;85(2):306-310. doi: 10.1097/MS9.0000000000000234. eCollection 2023 Feb.
Previous essays have presented possible concordance between obesity and colorectal polyp development. However, neither for the hypothesis nor for the details general consensus exists. This study aimed to evaluate the association between higher BMI rather than the normal and colorectal polyp presentation and characteristics if any.
Eligible patients based on study criteria who were candidates for total colonoscopy examination enrolled in this case-controlled trial. Controls had normal colonoscopy reports. A positive colonoscopy for any kind of polyp was followed by a histopathological study. Demographic data also was registered, and patients were categorized according to the calculated BMI. Groups were matched by both gender and status of tobacco abuse. Finally, the outcomes of colonoscopy and histopathological studies were compared between groups.
A total of 141 and 125 persons investigated, respectively, as patients and controls. Possible effects of gender, tobacco abuse, and cigarette smoking were declined by participants matching. Hence, we found no significant difference between groups regarding the latter variables (>0.05). Colorectal polyps were found absolutely more in BMI>25 kg/m rather than in lesser values (<0.001). However, there was no obvious difference in the incidence of colorectal polyps between groups categorized as overweight and obese (>0.05). Namely, even weighing over could be the risk for colorectal polyp development. Additionally, it was more expected to find neoplastic adenomatous polyp(s) with high-graded dysplasia in BMI>25 kg/m (<0.001).
Even little changes in BMI further than the normal values can independently increase the risk of developing dysplastic adenomatous colorectal polyp(s) significantly.
先前的文章提出了肥胖与结肠直肠息肉发生之间可能存在的一致性。然而，对于该假说及其细节均未达成普遍共识。本研究旨在评估较高体重指数（而非正常体重指数）与结肠直肠息肉的出现及特征（若有）之间的关联。
根据研究标准符合条件且拟进行全结肠镜检查的患者纳入本病例对照试验。对照组结肠镜检查报告正常。任何类型息肉的结肠镜检查阳性结果均需进行组织病理学研究。还记录了人口统计学数据，并根据计算出的体重指数对患者进行分类。按性别和烟草滥用状况对组进行匹配。最后，比较各组之间结肠镜检查和组织病理学研究的结果。
分别对141名患者和125名对照者进行了调查。通过参与者匹配降低了性别、烟草滥用和吸烟的可能影响。因此，我们发现两组在这些变量方面无显著差异（>0.05）。体重指数>25kg/m²的人群中结肠直肠息肉的检出率绝对高于较低值人群（<0.001）。然而，超重和肥胖组（>0.05）之间结肠直肠息肉的发生率无明显差异。也就是说，即使体重超标也可能是结肠直肠息肉发生的风险因素。此外，在体重指数>25kg/m²的人群中更有可能发现高级别发育异常的肿瘤性腺瘤性息肉（<0.001）。
即使体重指数比正常值有微小变化也能独立显著增加发生发育异常性腺瘤性结肠直肠息肉的风险。
