Schmidt Marius
Physics Department, University of Wisconsin-Milwaukee, 3135 North Maryland Avenue, Milwaukee, Wisconsin 53211, USA.
Struct Dyn. 2023 Feb 21;10(1):010901. doi: 10.1063/4.0000177. eCollection 2023 Jan.
Inspired by recent progress in time-resolved x-ray crystallography and the adoption of time-resolution by cryo-electronmicroscopy, this article enumerates several approaches developed to become bigger/smaller, faster, and better to gain new insight into the molecular mechanisms of life. This is illustrated by examples where chemical and physical stimuli spawn biological responses on various length and time-scales, from fractions of Ångströms to micro-meters and from femtoseconds to hours.
受时间分辨X射线晶体学的最新进展以及冷冻电子显微镜采用时间分辨率的启发，本文列举了几种为变大/变小、变快和变好而开发的方法，以深入了解生命的分子机制。这通过化学和物理刺激在从埃到微米的各种长度尺度以及从飞秒到小时的各种时间尺度上引发生物反应的例子来说明。
