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四磨汤治疗脾虚型便秘与脑-菌-肠轴通过肠道黏膜微生物群有关。

Simo decoction curing spleen deficiency constipation was associated with brain-bacteria-gut axis by intestinal mucosal microbiota.

作者信息

Yi Xin, Zhou Kang, Deng Na, Cai Ying, Peng Xinxin, Tan Zhoujin

机构信息

The Domestic First-class Discipline Construction Project of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.

出版信息

Front Microbiol. 2023 Feb 9;14:1090302. doi: 10.3389/fmicb.2023.1090302. eCollection 2023.

DOI:10.3389/fmicb.2023.1090302
PMID:36846756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9947565/
Abstract

BACKGROUND

Simo decoction (SMD) is a traditional prescription for treating gastrointestinal diseases. More and more evidences prove that SMD can treat constipation by regulating intestinal microbiota and related oxidative stress indicators, but the specific mechanism is still unclear.

METHODS

A network pharmacological analysis was used to predict the medicinal substances and potential targets of SMD to alleviate constipation. Then, 15 male mice were randomly divided into normal group (MN group), natural recovery group (MR group), and SMD treatment group (MT group). Constipation model mice were constructed by gavage of decoction and control of diet and drinking water, and SMD was used for intervention after successful modeling. The levels of 5-hydroxytryptamine (5-HT), vasoactive intestinal peptide (VIP), superoxide dismutase (SOD), malondialdehyde (MDA), and fecal microbial activities were measured, and the intestinal mucosal microbiota was sequenced.

RESULT

Network pharmacology analysis showed that a total of 24 potential active components were obtained from SMD, and 226 target proteins were obtained after conversion. Meanwhile, we obtained 1,273 and 424 disease-related targets in the GeneCards database and the DisGeNET database, respectively. After combination and deduplication, the disease targets shared 101 targets with the potential active components of SMD. When the mice were intervened with SMD, the 5-HT, VIP, MDA, SOD content, and microbial activity in MT group were close to MN group, and Chao 1 and ACE in MT group were significantly higher than that in MR group. In the Linear discriminant analysis Effect Size (LEfSe) analysis, the abundance of beneficial bacteria such as , , , , , and in MT group increased. At the same time, there were some associations between microbiota and brain-gut peptides and oxidative stress indicators.

CONCLUSION

SMD can promote intestinal health and relieve constipation through brain-bacteria-gut axis associating with intestinal mucosal microbiota and alleviate oxidative stress.

摘要

背景

四磨汤（SMD）是治疗胃肠道疾病的传统方剂。越来越多的证据表明，四磨汤可通过调节肠道微生物群和相关氧化应激指标来治疗便秘，但其具体机制仍不清楚。

方法

采用网络药理学分析预测四磨汤缓解便秘的药用物质和潜在靶点。然后，将15只雄性小鼠随机分为正常组（MN组）、自然恢复组（MR组）和四磨汤治疗组（MT组）。通过灌胃煎剂并控制饮食和饮水构建便秘模型小鼠，造模成功后用四磨汤进行干预。检测5-羟色胺（5-HT）、血管活性肠肽（VIP）、超氧化物歧化酶（SOD）、丙二醛（MDA）水平及粪便微生物活性，并对肠道黏膜微生物群进行测序。

结果

网络药理学分析显示，从四磨汤中共获得24种潜在活性成分，转化后得到226个靶蛋白。同时，我们在GeneCards数据库和DisGeNET数据库中分别获得1273个和424个疾病相关靶点。经过合并和去重后，疾病靶点与四磨汤潜在活性成分共有101个靶点。当用四磨汤干预小鼠时，MT组的5-HT、VIP、MDA、SOD含量及微生物活性接近MN组，MT组的Chao 1和ACE显著高于MR组。在线性判别分析效应大小（LEfSe）分析中，MT组中有益菌如、、、、、和的丰度增加。同时，微生物群与脑肠肽和氧化应激指标之间存在一些关联。

结论

四磨汤可通过与肠道黏膜微生物群相关的脑-菌-肠轴促进肠道健康、缓解便秘并减轻氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ffc/9947565/29e08d22e88e/fmicb-14-1090302-g010.jpg
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