Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang 318000, Zhejiang, China.
Org Biomol Chem. 2023 Mar 15;21(11):2355-2360. doi: 10.1039/d3ob00083d.
Herein, we report a novel, rapid and efficient route to the spiroquinazolinone framework an umpolung strategy mediated by molecular iodine. A library of functionalized spiroquinazolinone iodide salts was synthesized in moderate to good yields under ambient, metal-free and mild conditions. The current methodology opens up a new efficient and concise strategy for the construction of spiroquinazolinones.
本文报道了一种新颖、快速且高效的螺环喹唑啉酮骨架构建方法，该方法通过碘介导的反转策略实现。在温和、无金属条件下，以中等至良好的收率合成了一系列功能化螺环喹唑啉酮碘盐。该方法为螺环喹唑啉酮的构建提供了一种新的高效、简洁的策略。
