自噬与肾脏衰老。
Autophagy and kidney aging.
机构信息
Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Department of Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan.
出版信息
Prog Biophys Mol Biol. 2023 May;179:10-15. doi: 10.1016/j.pbiomolbio.2023.02.005. Epub 2023 Feb 26.
Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In recent years, it has become clear that autophagy becomes dysregulated with aging, which leads to age-related diseases. Kidney function is particularly prone to age-related decline, and aging is the most significant risk factor for chronic kidney disease. This review first discuss the relationship between autophagy and kidney aging. Second, we describe how age-related dysregulation of autophagy occurs. Finally, we discuss the potential of autophagy-targeting drugs to ameliorate human kidney aging and the approaches necessary to discover such agents.
自噬是真核生物中一种高度保守的细胞内降解系统，可维持细胞和组织的内稳态。在自噬诱导后，细胞质成分被一种称为自噬体的双层膜细胞器包裹，自噬体与溶酶体融合以降解其内容物。近年来，自噬在衰老过程中出现失调已变得清晰，这导致了与年龄相关的疾病。肾脏功能尤其容易随年龄下降，而衰老则是慢性肾脏病的最大危险因素。本综述首先讨论了自噬与肾脏衰老的关系。其次，我们描述了自噬随年龄相关失调的发生机制。最后，我们讨论了自噬靶向药物改善人类肾脏衰老的潜力，以及发现此类药物所必需的方法。
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