Vera-Lastra Olga, Mora Gabriela, Lucas-Hernández Abihai, Ordinola-Navarro Alberto, Rodríguez-Chávez Emmanuel, Peralta-Amaro Ana Lilia, Medina Gabriela, Cruz-Dominguez María Pilar, Jara Luis J, Shoenfeld Yehuda
Internal Medicine Department, Hospital de Especialidades, Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Mexico City 02990, Mexico.
Inmunology Department, Hospital Militar Central, Cirujano Mayor Dr. Cosme Argerich, Buenos Aires C1426, Argentina.
Biomedicines. 2023 Jul 4;11(7):1898. doi: 10.3390/biomedicines11071898.
The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed the development of a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients and Methods: A retrospective study was conducted on patients with new-onset autoimmune diseases induced by a post-COVID-19 vaccine between March 2021 and December 2022, in two referral hospitals in Mexico City and Argentina. The study evaluated patients who received the Sputnik vaccine and developed recent-onset autoimmune diseases. Results: Twenty-eight patients developed recent-onset autoimmune diseases after Sputnik vaccine. The median age was 56.9 ± 21.7 years, with 14 females and 14 males. The autoimmune diseases observed were neurological in 13 patients (46%), hematological autoimmune manifestations occurred in 12 patients (42%), with thrombotic disease observed in 10 patients (28%), and autoimmune hemolytic anemia in two patients (7.1%). Rheumatological disorders were present in two patients (7.1%), and endocrine disorders in one patient (3.5%). Principio del formulario Conclusion: Although the COVID-19 Sputnik vaccine is generally safe, it can lead to adverse effects. Thrombosis and Guillain-Barre were the most frequent manifestations observed in our group of patients.
对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）基因组序列的迅速确定使得包括基于信使核糖核酸（mRNA）的疫苗、灭活病毒疫苗、蛋白亚单位疫苗以及如卫星五号（Sputnik）腺病毒疫苗在内的多种疫苗得以研发。本研究旨在报告接种新冠病毒卫星五号疫苗后出现的自身免疫性疾病表现。患者与方法：对2021年3月至2022年12月期间在墨西哥城和阿根廷的两家转诊医院中因接种新冠疫苗后引发新发自身免疫性疾病的患者进行了一项回顾性研究。该研究评估了接种卫星五号疫苗并出现新发自身免疫性疾病的患者。结果：28名患者在接种卫星五号疫苗后出现了新发自身免疫性疾病。中位年龄为56.9±21.7岁，其中女性14名，男性14名。观察到的自身免疫性疾病中，13名患者（46%）为神经系统疾病，12名患者（42%）出现血液学自身免疫表现，10名患者（28%）出现血栓性疾病，2名患者（7.1%）出现自身免疫性溶血性贫血。2名患者（7.1%）出现风湿性疾病，1名患者（3.5%）出现内分泌疾病。结论：尽管新冠病毒卫星五号疫苗总体上是安全的，但它可能会导致不良反应。血栓形成和吉兰-巴雷综合征是我们研究组患者中最常见的表现。
