Li Guoming, Zheng Shaoqin, Zhang Zhenyan, Hu Yanshan, Lin Nansong, Julie Nadia, Shu Lei, Sun Liwei, Zhang Hongying, Yuan Yueming, Liang Yuan, Yu Zhengjie, Xie Wei, Mwaisiga Ridley, Morewaya Jacob, Xu Qin, Song Jianping, Deng Changsheng
Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Institute of Science and Technology Park, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Prev Med Rep. 2023 Feb 16;32:102154. doi: 10.1016/j.pmedr.2023.102154. eCollection 2023 Apr.
We conducted a study on the Trobriand Islands of Papua New Guinea (PNG) in 2018 to verify the safety and efficacy of the artemisinin-piperaquine (AP) mass drug administration (MDA) campaign in regions with moderate to high mixed malaria transmission. Based on the natural topography of the Trobriand Islands, 44,855 residents from 92 villages on the islands were enrolled and divided into the main and outer islands. Three rounds of MDA were conducted using grid-based management. The primary endpoint was the coverage rate. Adverse reactions, parasitemia, and malaria morbidity were the secondary endpoints. There were 36,716 people living in 75 villages on the main island, and the MDA coverage rate was 92.58-95.68%. Furthermore, 8,139 people living in 17 villages on the outer islands had a coverage rate of 94.93-96.11%. The adverse reactions were mild in both groups, and parasitemia decreased by 87.2% after one year of surveillance. The average annual malaria morbidity has decreased by 89.3% after the program for four years. High compliance and mild adverse reactions indicated that the MDA campaign with AP was safe. The short-term effect is relatively ideal, but the evidence for long-term effect evaluation is insufficient.
2018年，我们在巴布亚新几内亚（PNG）的特罗布里恩群岛开展了一项研究，以验证在疟疾混合传播程度为中度至高的地区开展青蒿素-哌喹（AP）大规模药物给药（MDA）活动的安全性和有效性。根据特罗布里恩群岛的自然地形，该群岛92个村庄的44855名居民被纳入研究，并分为主岛和外岛。采用网格化管理开展了三轮MDA。主要终点是覆盖率。不良反应、寄生虫血症和疟疾发病率为次要终点。主岛75个村庄有36716人，MDA覆盖率为92.58%-95.68%。此外，外岛17个村庄的8139人覆盖率为94.93%-96.11%。两组的不良反应均较轻，监测一年后寄生虫血症下降了87.2%。该项目实施四年后，年平均疟疾发病率下降了89.3%。高依从性和轻微的不良反应表明，使用AP开展的MDA活动是安全的。短期效果相对理想，但长期效果评估的证据不足。
