Wang Mengyue, Li Chunlin, Zhang Wenjing, Chen Renji, Li Xia
School of Biomedical Engineering, Capital Medical University, Beijing 100069, P. R. China.
Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Feb 25;40(1):125-132. doi: 10.7507/1001-5515.202006068.
The cleft lip and palate (CLP) is one of the most common craniofacial malformations in humans. We collected functional magnetic resonance data of 23 CLP patients before rehabilitation training (Bclp) and 23 CLP patients after rehabilitation training (Aclp), who were performing Chinese character pronunciation tasks, and performed brain activation analysis to explore the changes of brain mechanism in CLP patients after articulation disorder rehabilitation training. The study found that Aclp group had significant activation in the motor cortex, Broca area, Wernicke area and cerebellum. While the Bclp group had weak activation in the motor cortex with a small activation range. By comparing the differences and co-activated brain regions between the two groups, we found that rehabilitation training increased the activity level of negatively activated brain areas (cerebellum, left motor area, Wernicke area, etc.) to a positive level. At the same time, the activity level of weakly activated brain areas (right motor area, Broca area, etc.) was also increased. Rehabilitation training promoted the activity level of articulation-related brain regions. So that the activation intensity of articulation-related brain regions can be used as a quantifiable objective evaluation index to evaluate the effect of rehabilitation training, which is of great significance for the formulation of rehabilitation training programs.
唇腭裂（CLP）是人类最常见的颅面畸形之一。我们收集了23例唇腭裂患者康复训练前（Bclp）和23例唇腭裂患者康复训练后（Aclp）在进行汉字发音任务时的功能磁共振数据，并进行脑激活分析，以探讨构音障碍康复训练后唇腭裂患者脑机制的变化。研究发现，Aclp组在运动皮层、布洛卡区、韦尼克区和小脑有显著激活。而Bclp组在运动皮层的激活较弱，激活范围较小。通过比较两组之间的差异和共同激活的脑区，我们发现康复训练将负激活脑区（小脑、左侧运动区、韦尼克区等）的活动水平提高到了正激活水平。同时，弱激活脑区（右侧运动区、布洛卡区等）的活动水平也有所提高。康复训练促进了与构音相关脑区的活动水平。从而使与构音相关脑区的激活强度可作为量化的客观评估指标来评价康复训练效果，这对康复训练方案的制定具有重要意义。
