2008年越南孕妇中未发现寨卡病毒。
Absence of Zika virus among pregnant women in Vietnam in 2008.
作者信息
Chiu Y-C, Baud D, Fahmi A, Zumkehr B, Vouga M, Pomar L, Musso D, Thuong B C, Alves M P, Stojanov M
机构信息
Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
出版信息
Trop Dis Travel Med Vaccines. 2023 Mar 1;9(1):4. doi: 10.1186/s40794-023-00189-7.
BACKGROUND
Despite being first identified in 1947, Zika virus-related outbreaks were first described starting from 2007 culminating with the 2015 Latin American outbreak. Hypotheses indicate that the virus has been circulating in Asia for decades, but reports are scarce.
METHODS
We performed serological analysis and screened placental samples isolated in 2008 for the presence of Zika virus from pregnant women in Ho Chi Minh City (Vietnam).
RESULTS
None of the placental samples was positive for Zika virus. Four serum samples out of 176 (2.3%) specifically inhibited Zika virus, with variable degrees of cross-reactivity with other flaviviruses. While one of the four samples inhibited only Zika virus, cross-reactivity with other flaviviruses not included in the study could not be ruled out.
CONCLUSION
Our results support the conclusion that the virus was not present among pregnant women in the Vietnamese largest city during the initial phases of the epidemic wave.
背景
尽管寨卡病毒于1947年首次被发现，但寨卡病毒相关疫情最早是从2007年开始描述的，最终在2015年拉丁美洲爆发达到顶峰。有假设表明该病毒已在亚洲传播数十年，但相关报道很少。
方法
我们对2008年从越南胡志明市孕妇中分离的胎盘样本进行了血清学分析，并筛查了寨卡病毒的存在情况。
结果
所有胎盘样本的寨卡病毒检测均为阴性。176份血清样本中有4份（2.3%）能特异性抑制寨卡病毒，与其他黄病毒存在不同程度的交叉反应。虽然这4份样本中的1份仅抑制寨卡病毒，但不能排除与本研究未纳入的其他黄病毒存在交叉反应。
结论
我们的结果支持以下结论，即在疫情初期，越南最大城市的孕妇中不存在该病毒。
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