Pôle de Recherche et de Veille sur les Maladies Infectieuses Émergentes, Institut Louis Malardé, Paea, Tahiti, French Polynesia.
Unité d'Entomologie Médicale, Institut Louis Malardé, Paea, Tahiti, French Polynesia.
Lancet Infect Dis. 2018 May;18(5):e172-e182. doi: 10.1016/S1473-3099(17)30446-2. Epub 2017 Nov 14.
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays. We describe the effect of this outbreak on health systems, the implementation of vector-borne control strategies, and the line of communication used to alert the international community of the new risk associated with Zika virus. This outbreak highlighted the need for careful monitoring of all unexpected events that occur during an emergence, to implement surveillance and research programmes in parallel to management of cases, and to be prepared to the worst-case scenario.
寨卡病毒危机凸显了与新出现的病原体相关的风险，提醒人们尽管准备最坏情况具有挑战性，但仍有必要这样做。在此，我们回顾了 2013 年末法属波利尼西亚意外出现寨卡病毒期间报告的所有数据。我们重点介绍了此次疫情爆发期间报告的新发现，尤其是首次描述了成年人的严重神经并发症和对 CNS 畸形的回顾性描述，寨卡病毒在精液中的分离，血液传播的可能性，母婴传播以及新诊断检测方法的开发。我们描述了此次疫情对卫生系统的影响，病媒传播控制策略的实施以及用于向国际社会发出与寨卡病毒相关的新风险警报的沟通渠道。此次疫情突显了需要仔细监测在疫情期间发生的所有意外事件，以实施与病例管理并行的监测和研究计划，并为最坏情况做好准备。
