早期骨关节炎问卷（EOAQ）：一种在初始阶段评估膝关节骨关节炎的工具。
Early Osteoarthritis Questionnaire (EOAQ): a tool to assess knee osteoarthritis at initial stage.
作者信息
Migliore Alberto, Alekseeva Liudmila, Avasthi Sachin R, Bannuru Raveendhara R, Chevalier Xavier, Conrozier Thierry, Crimaldi Sergio, de Campos Gustavo C, Diracoglu Demirhan, Gigliucci Gianfranco, Herrero-Beaumont Gabriel, Iolascon Giovanni, Ionescu Ruxandra, Jerosch Jörg, Lains Jorge, Maheu Emmanuel, Makri Souz, Martusevich Natalia, Matucci-Cerinic Marco, Pavelka Karen, Petrella Robert J, Raman Raghu, Tarantino Umberto
机构信息
Rheumatology Unit, San Pietro Fatebenefratelli Hospital, Via Cassia 600- 00189, Rome, Italy.
Department of Metabolic Diseases of Bone and Joints, VA Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
出版信息
Ther Adv Musculoskelet Dis. 2023 Feb 25;15:1759720X221131604. doi: 10.1177/1759720X221131604. eCollection 2023.
BACKGROUND
Early stage of osteoarthritis (OA) is characterized by joint stiffness and pain as well as by subclinical structural changes that may affect cartilage, synovium, and bone. At the moment, the lack of a validated definition of early osteoarthritis (EOA) does not allow to make an early diagnosis and adopt a therapeutic strategy to slow disease progression. Also, no questionnaires are available to evaluate the early stage, and therefore this remains an unmet need.
OBJECTIVE
Therefore, the purpose of the technical experts panel (TEP) of 'International Symposium of intra-articular treatment' (ISIAT) was to create a specific questionnaire to evaluate and monitor the follow-up and clinical progress of patients affected by early knee OA.
DESIGN
The items for the Early Osteoarthritis Questionnaire (EOAQ) were identified according to the following steps: items generation, items reduction, and pre-test submission.
METHODS
During the first step, literature has been reviewed and a comprehensive list of items about pain and function in knee EOA was drafted. Then, during the ISIAT (5th edition 2019), the draft has been discussed by the board, which reformulated, deleted, or subdivided some of the items. After the ISIAT symposium, the draft was submitted to 24 subjects affected by knee OA. A score based on the importance and the frequency was created and the items with a score ⩾0.75 were selected. After intermediate evaluation made by a sample of patients, the second and final version of the questionnaire EOAQ was submitted to the whole board for final analysis and acceptance in a second meeting (29 January 2021).
RESULTS
After an exhaustive elaboration, the final version of the questionnaire contains two domains (Clinical Features and Patients Reported Outcome) with respectively 2 and 9 questions, for a total of 11 questions. Questions mainly explored the fields of early symptoms and patients reported outcomes. Marginally, the need of the symptoms treatment and the use of painkillers were investigated.
CONCLUSIONS
Adoption of diagnostic criteria of early OA is strongly encouraged and a specific questionnaire for the whole management of the clinical features and patients' outcome might really improve the evolution of OA in the early stages of the disease, when the treatment is expected to be more effective.
背景
骨关节炎（OA）早期的特征是关节僵硬、疼痛以及可能影响软骨、滑膜和骨骼的亚临床结构变化。目前，由于缺乏经过验证的早期骨关节炎（EOA）定义，无法进行早期诊断并采取治疗策略来减缓疾病进展。此外，尚无用于评估早期阶段的问卷，因此这仍是未满足的需求。
目的
因此，“关节内治疗国际研讨会”（ISIAT）技术专家小组（TEP）的目的是创建一份特定问卷，以评估和监测早期膝关节OA患者的随访情况及临床进展。
设计
早期骨关节炎问卷（EOAQ）的条目按照以下步骤确定：条目生成、条目缩减和预测试提交。
方法
在第一步中，查阅了文献并起草了一份关于膝关节早期骨关节炎疼痛和功能的综合条目清单。然后，在ISIAT（2019年第5版）期间，委员会对该草案进行了讨论，重新制定、删除或细分了一些条目。ISIAT研讨会之后，该草案提交给24名膝关节OA患者。创建了一个基于重要性和频率的评分，选择了得分⩾0.75的条目。在患者样本进行中间评估之后，问卷EOAQ的第二版也是最终版提交给整个委员会，以便在第二次会议（2021年1月29日）进行最终分析并获得认可。
结果
经过详尽的拟定，问卷的最终版包含两个领域（临床特征和患者报告结局），分别有2个和9个问题，共计11个问题。问题主要探讨了早期症状和患者报告结局领域。在一定程度上，还调查了症状治疗需求和止痛药的使用情况。
结论
强烈鼓励采用早期OA的诊断标准，一份用于全面管理临床特征和患者结局的特定问卷可能真的会改善OA在疾病早期的进展情况，此时治疗预计会更有效。
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