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炎症性肠病患者眼部肠外表现发病率的分析:一项系统评价

Analysis of the Incidence of Ocular Extraintestinal Manifestations in Inflammatory Bowel Disease Patients: A Systematic Review.

作者信息

Songel-Sanchis Bruno, Cosín-Roger Jesús

机构信息

Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia, Av. Blasco Ibáñez, 15, 46010 Valencia, Spain.

出版信息

Diagnostics (Basel). 2024 Dec 14;14(24):2815. doi: 10.3390/diagnostics14242815.

DOI:10.3390/diagnostics14242815
PMID:39767176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11675585/
Abstract

: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, primarily affects the gastrointestinal tract. Additionally, extraintestinal manifestations may occur in the liver, musculoskeletal system and eyes. Its etiology remains unknown, and further research is required in order to develop pharmacological drugs which achieve complete remission of the pathology. : The aim of this study was to analyze the incidence of ocular extraintestinal manifestations in IBD patients. : A total of six searches were carried out on the medical publication server "" in June and July 2024, using different keywords; a total of 323 results were obtained, of which 34 were finally selected for study. : Ocular extraintestinal manifestations in IBD patients are more common in the anterior pole of the eye, with uveitis, scleritis and episcleritis being the most usual ones. In the case of the posterior pole, the most common manifestations are posterior uveitis and optic neuritis. : The incidence of ocular complications whose origin is inflammatory, such as uveitis, scleritis, episcleritis and neuritis, is higher than that of complications of non-inflammatory origin.

摘要

炎症性肠病(IBD),包括克罗恩病和溃疡性结肠炎,主要影响胃肠道。此外,还可能出现肝脏、肌肉骨骼系统和眼部的肠外表现。其病因尚不清楚,需要进一步研究以开发能使病情完全缓解的药物。

本研究的目的是分析炎症性肠病患者眼部肠外表现的发生率。

2024年6月和7月,在医学出版物服务器“”上共进行了六次搜索,使用了不同的关键词;共获得323条结果,最终选择了34条进行研究。

炎症性肠病患者的眼部肠外表现在眼的前极更为常见,葡萄膜炎、巩膜炎和表层巩膜炎最为常见。在后极的情况下,最常见的表现是后葡萄膜炎和视神经炎。

起源于炎症的眼部并发症,如葡萄膜炎、巩膜炎、表层巩膜炎和神经炎的发生率高于非炎症性起源的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aa1/11675585/494930f2ed81/diagnostics-14-02815-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aa1/11675585/494930f2ed81/diagnostics-14-02815-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aa1/11675585/494930f2ed81/diagnostics-14-02815-g001.jpg

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本文引用的文献

1
Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.炎症性肠病在先进治疗时代的年龄分布流行病学。
J Crohns Colitis. 2024 Oct 30;18(Supplement_2):ii3-ii15. doi: 10.1093/ecco-jcc/jjae082.
2
Anterior uveitis for the comprehensive ophthalmologist.综合眼科医生眼中的前葡萄膜炎。
Can J Ophthalmol. 2025 Apr;60(2):69-78. doi: 10.1016/j.jcjo.2024.07.013. Epub 2024 Aug 8.
3
The Prevalence and Characteristics of Inflammatory Bowel Disease-related Ocular Involvement in Children.儿童炎症性肠病相关眼部受累的患病率及特征
Inflamm Bowel Dis. 2025 May 12;31(5):1256-1262. doi: 10.1093/ibd/izae160.
4
Manifestations and Management of Inflammatory Eye Disease in Patients with Inflammatory Bowel Disease.炎症性肠病患者的眼部炎症性疾病的表现和治疗。
Ocul Immunol Inflamm. 2024 Dec;32(10):2348-2353. doi: 10.1080/09273948.2024.2362881. Epub 2024 Jun 7.
5
Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study.儿童炎症性肠病中慢性葡萄膜炎的患病率和临床特征:一项全国性研究。
J Pediatr Gastroenterol Nutr. 2024 Jun;78(6):1305-1309. doi: 10.1002/jpn3.12216. Epub 2024 Apr 9.
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Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.炎症性肠病肠外表现的综合关联分析。
Gastroenterology. 2024 Jul;167(2):315-332. doi: 10.1053/j.gastro.2024.02.026. Epub 2024 Mar 13.
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Dry Eye Syndrome Preferred Practice Pattern®.干眼综合征首选诊疗模式®
Ophthalmology. 2024 Apr;131(4):P1-P49. doi: 10.1016/j.ophtha.2023.12.041. Epub 2024 Feb 12.
8
AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.AGA 临床实践更新:炎症性肠病患者的饮食和营养治疗:专家综述。
Gastroenterology. 2024 Mar;166(3):521-532. doi: 10.1053/j.gastro.2023.11.303. Epub 2024 Jan 23.
9
Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD.SPARC-IBD 中与炎症性肠病肠外表现相关的因素
Inflamm Bowel Dis. 2024 Nov 4;30(11):2027-2036. doi: 10.1093/ibd/izad280.
10
Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study.炎症性肠病与干眼和眼表面损伤的相关风险:一项全国性匹配队列研究。
BMC Ophthalmol. 2023 Oct 13;23(1):415. doi: 10.1186/s12886-023-03165-z.