Indzhova Viktoriya, Czopowicz Michał, Kilpatrick Scott, Gutierrez-Quintana Rodrigo, Brocal Josep
Willows Veterinary Centre and Referral Service, Part of Linnaeus Veterinary Limited, Solihull, United Kingdom.
Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.
Front Vet Sci. 2023 Feb 14;10:1091318. doi: 10.3389/fvets.2023.1091318. eCollection 2023.
This retrospective multicentric study aims to evaluate the ability of CRP concentration to differentiate between dogs diagnosed with IMPA and SRMA. C-reactive protein (CRP) is a marker of inflammation widely used in two of the most commonly diagnosed immune-mediated diseases in dogs-Immune-mediated polyarthritis (IMPA) and steroid responsive meningitis arteritis (SRMA).
Data collected from medical records of 167 client-owned dogs included age, breed, gender, neuter status, body weight, body temperature, CRP concentration, month and season of diagnosis. CRP was measured quantitatively in 142 dogs (84%) and semi-quantitatively in 27 dogs (16%).
SRMA was diagnosed significantly more often in dogs < 12 months old and IMPA in dogs ≥12 months old ( < 0.001). Dogs diagnosed with SRMA had higher CRP concentration than dogs diagnosed with IMPA ( = 0.02). This difference was influenced by the dog's age-when a dog was <12 months old, a higher CRP concentration indicated IMPA ( = 0.02), whereas when a dog was ≥12 months old, a higher CRP concentration indicated SRMA ( = 0.02).
CRP concentration as a sole diagnostic modality showed only fair discriminatory potential to differentiate between SRMA and IMPA (area under ROC curve close to 0.7). CRP concentration varied depending on patient age and definitive diagnosis. It may play some role in differentiating between SRMA and IMPA but should not be used as the sole diagnostic modality, given it has been demonstrated to only have fair discriminatory potential.
本回顾性多中心研究旨在评估C反应蛋白（CRP）浓度区分诊断为免疫介导性多关节炎（IMPA）和类固醇反应性脑膜炎动脉炎（SRMA）的犬只的能力。C反应蛋白（CRP）是一种炎症标志物，广泛应用于犬类最常见的两种免疫介导性疾病——免疫介导性多关节炎（IMPA）和类固醇反应性脑膜炎动脉炎（SRMA）。
从167只客户拥有的犬只的病历中收集的数据包括年龄、品种、性别、绝育状态、体重、体温、CRP浓度、诊断月份和季节。142只犬（84%）进行了CRP定量测量，27只犬（16%）进行了半定量测量。
SRMA在12个月龄以下的犬只中诊断更为频繁，而IMPA在12个月龄及以上的犬只中诊断更为频繁（<0.001）。诊断为SRMA的犬只的CRP浓度高于诊断为IMPA的犬只（=0.02）。这种差异受犬只年龄的影响——当犬只<12个月龄时，较高的CRP浓度表明为IMPA（=0.02），而当犬只≥12个月龄时，较高的CRP浓度表明为SRMA（=0.02）。
CRP浓度作为唯一的诊断方式，在区分SRMA和IMPA方面仅显示出一般的鉴别潜力（ROC曲线下面积接近0.7）。CRP浓度因患者年龄和最终诊断而异。它可能在区分SRMA和IMPA方面发挥一定作用，但不应作为唯一的诊断方式，因为已证明其仅具有一般的鉴别潜力。
