Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Cell Rep. 2023 Mar 28;42(3):112200. doi: 10.1016/j.celrep.2023.112200. Epub 2023 Mar 1.
Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states.
丘脑网状核回路在觉醒、注意、认知和睡眠纺锤波中发挥着关键作用，与多种脑部疾病有关。我们已经开发了一个详细的小鼠体感丘脑和丘脑网状核的计算模型，以捕捉由 600 万个突触连接的超过 14000 个神经元的特性。该模型再现了这些神经元的生物连通性，并且模型的模拟在不同的大脑状态下再现了多个实验结果。该模型表明，在清醒状态下，抑制性反弹会产生对丘脑反应的频率选择性增强。我们发现，丘脑相互作用是纺锤波振荡特征性起伏的原因。此外，我们发现，丘脑兴奋性的变化控制着纺锤波的频率及其发生率。该模型是公开提供的，为研究不同大脑状态下丘脑网状核回路的功能和功能障碍提供了新的工具。
