1990年至2019年常见癌症因代谢风险所致的全球负担。

Global burden of common cancers attributable to metabolic risks from 1990 to 2019.

作者信息

Xing Qing-Qing, Li Jing-Mao, Chen Zhi-Jian, Lin Xiao-Yun, You Yan-Ying, Hong Mei-Zhu, Weng Shangeng, Pan Jin-Shui

机构信息

Department of Hepatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China; Hepatology Research Institute, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Clinical Research Center for Liver and Intestinal Diseases, Fuzhou, Fujian 350005, China.

Department of Statistics, School of Economics, Xiamen University, Xiamen, Fujian 361000, China.

出版信息

Med. 2023 Mar 10;4(3):168-181.e3. doi: 10.1016/j.medj.2023.02.002. Epub 2023 Mar 2.

DOI:10.1016/j.medj.2023.02.002

PMID:36868237

Abstract

BACKGROUND

Non-alcoholic fatty liver disease (NAFLD) is usually accompanied by metabolic syndrome, which is associated with increased risk of cancer. To inform a tailored cancer screen in patients at higher risks, we estimated the global burden of cancer attributable to metabolic risks.

METHODS

Data of common metabolism-related neoplasms (MRNs) were derived from the Global Burden of Disease (GBD) 2019 database. Age-standardized, disability-adjusted life year (DALY) rates and death rates of patients with MRNs were extracted from the GBD 2019 database and stratified by metabolic risk, sex, age, and level of socio-demographic index (SDI). The annual percentage changes of age-standardized DALYs and death rates were calculated.

FINDINGS

Metabolic risks, consisting of high body mass index and fasting plasma glucose, contributed substantially to the burden of neoplasms, including colorectal cancer (CRC), tracheal, bronchus, and lung cancer (TBLC), etc. Globally, in 2019, there was an estimated age-standardized DALY rate (ASDR) of 234 (95% confidence interval [CI] 124-376) per 100,000 person years for neoplasms attributable to metabolic risks. ASDRs of MRNs were higher for CRC, TBLC, men, patients aged ≥50 years, and patients with high or high-middle SDI.

CONCLUSIONS

The findings of this study further underpin the correlation between NAFLD and intrahepatic and extrahepatic cancers and highlight the possibility of tailored cancer screening for the NAFLD population at higher risks.

FUNDING

This work was supported by the National Natural Science Foundation of China and Natural Science Foundation of Fujian Province of China.

摘要

背景

非酒精性脂肪性肝病（NAFLD）通常伴有代谢综合征，而代谢综合征与癌症风险增加相关。为了为高危患者制定个性化的癌症筛查方案，我们估算了代谢风险所致癌症的全球负担。

方法

常见代谢相关肿瘤（MRN）的数据来自《2019年全球疾病负担（GBD）》数据库。从GBD 2019数据库中提取MRN患者的年龄标准化残疾调整生命年（DALY）率和死亡率，并按代谢风险、性别、年龄和社会人口学指数（SDI）水平进行分层。计算年龄标准化DALY和死亡率的年度百分比变化。

研究结果

由高体重指数和空腹血糖组成的代谢风险在很大程度上导致了包括结直肠癌（CRC）、气管、支气管和肺癌（TBLC）等在内的肿瘤负担。在全球范围内，2019年，归因于代谢风险的肿瘤的年龄标准化DALY率（ASDR）估计为每10万人年234（95%置信区间[CI]124 - 376）。CRC、TBLC、男性、年龄≥50岁的患者以及高或高中等SDI患者的MRN的ASDR更高。