来自多瓣金花茶的五种新齐墩果烷型三萜皂苷及其α-葡萄糖苷酶抑制活性
Five New Oleanane Triterpene Saponins from Camellia petelotii and Their Alpha-glucosidase Inhibitory Activity.
作者信息
Thi Cuc Nguyen, Anh Bang Ngo, Huu Tai Bui, Xuan Nhiem Nguyen, Hai Yen Pham, Thi Hai Yen Duong, Thi Thu Hien Truong, Thi Huyen Le, Van Kiem Phan
机构信息
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
出版信息
Chem Biodivers. 2023 Apr;20(4):e202300093. doi: 10.1002/cbdv.202300093. Epub 2023 Mar 17.
Five new triterpenoid glycosides, named campetelosides A-E (1-5), together with three known compounds, chikusetsusaponin IVa (6), umbellatoside B (7), and silvioside E (8) were isolated from the leaves of Camellia petelotii (Merr.) Sealy. Their chemical structures were determined by interpretations of HR-ESI-MS and NMR spectra. In addition, compounds 1-8 were evaluated for their α-glucosidase inhibitory effects. Compounds 1-3 significantly showed α-glucosidase inhibitory activity with IC values of 166.7±6.0, 45.9±2.6, and 395.3±10.5 μM, respectively, compared to that of the positive control, acarbose, with an IC value of 200.4±10.5 μM.
从大苞山茶（Camellia petelotii (Merr.) Sealy）的叶子中分离出了5种新的三萜糖苷，命名为大苞山苷A - E（1 - 5），以及3种已知化合物，七叶皂苷IVa（6）、伞形花苷B（7）和银叶苷E（8）。通过高分辨电喷雾电离质谱（HR - ESI - MS）和核磁共振谱（NMR）的解析确定了它们的化学结构。此外，还评估了化合物1 - 8对α - 葡萄糖苷酶的抑制作用。与阳性对照阿卡波糖（IC值为200.4±10.5 μM）相比，化合物1 - 3分别以166.7±6.0、45.9±2.6和395.3±10.5 μM的IC值显著显示出α - 葡萄糖苷酶抑制活性。
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