Prowse C V, Waterston Y, Dawes J, McClelland D B, Gillon J
Edinburgh and South-East Scotland Blood Transfusion Service, Royal Infirmary, UK.
Vox Sang. 1987;53(3):129-34. doi: 10.1111/j.1423-0410.1987.tb04935.x.
An approach to the full assessment of new plasmapheresis machines is outlined. This involves testing for changes in donated blood, donors and blood components using fresh donor blood and during full procedures in an animal model prior to performing full procedures in human volunteers. Using this approach, a new centrifugal plasmapheresis machine, the SPC-600, was assessed. No adverse effects associated with the use of the machine were detected in the initial studies. When used for plasmapheresis of volunteers, 500 ml of plasma was obtained in 43 +/- 4 min without adverse effects on donors. The plasma product contained normal levels of plasma proteins, including factor VIII, and 20 +/- 6 X 10(9)/1 platelets. There was no evidence of activation of complement or coagulation systems, and the factor VIII yield in cryoprecipitate prepared from single donations of plasma was equivalent to that observed for standard whole blood donations.
概述了一种对新型血浆置换机进行全面评估的方法。这包括在人类志愿者进行完整程序之前，使用新鲜献血者血液并在动物模型的完整程序中，测试对捐献血液、献血者和血液成分的影响。采用这种方法，对一种新型离心式血浆置换机SPC - 600进行了评估。在初始研究中未检测到与使用该机器相关的不良反应。当用于志愿者的血浆置换时，在43±4分钟内获得了500毫升血浆，且对献血者没有不良影响。血浆产品中血浆蛋白水平正常，包括凝血因子VIII，且含有20±6×10⁹/升血小板。没有补体或凝血系统激活的证据，从单次捐献的血浆制备的冷沉淀物中凝血因子VIII的产量与标准全血捐献所观察到的产量相当。
