Division of Tropical and Infectious Disease, Internal Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Division of Tropical and Infectious Disease, Internal Medicine Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Malar J. 2023 Mar 5;22(1):77. doi: 10.1186/s12936-023-04493-7.
Some anti-malarial drugs often cause haemolytic anaemia in glucose-6-phosphate-dehydrogenase deficiency (G6PDd) patients. This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs.
A literature search was performed in major database portals. All studies searched using keywords with Medical Subject Headings (MeSH) were included, without date or language restriction. Pooled mean difference of haemoglobin and risk ratio of anaemia were analysed using RevMan.
Sixteen studies comprising 3474 malaria patients that included 398 (11.5%) with G6PDd were found. Mean difference of haemoglobin in G6PDd/G6PD normal (G6PDn) patients was - 0.16 g/dL (95% CI - 0.48, 0.15; I 5%, p = 0.39), regardless of the type of malaria and dose of drugs. In particular with primaquine (PQ), mean difference of haemoglobin in G6PDd/G6PDn patients with dose < 0.5 mg/kg/day was - 0.04 (95% CI - 0.35, 0.27; I 0%, p = 0.69). The risk ratio of developing anaemia in G6PDd patients was 1.02 (95% CI 0.75, 1.38; I 0%, p = 0.79).
Single or daily standard doses of PQ (0.25 mg/kg/day) and weekly PQ (0.75 mg/kg/week) did not increase the risk of anaemia in G6PDd patients.
一些抗疟药物常导致葡萄糖-6-磷酸脱氢酶缺乏症（G6PDd）患者发生溶血性贫血。本研究旨在分析 G6PDd 与接受抗疟药物治疗的疟疾患者贫血之间的关系。
在主要数据库门户中进行文献检索。使用带有医学主题词（MeSH）的关键词进行搜索，无日期或语言限制。使用 RevMan 分析血红蛋白的合并均数差和贫血的风险比。
共检索到 16 项研究，包含 3474 例疟疾患者，其中 398 例（11.5%）患有 G6PDd。G6PDd/G6PD 正常（G6PDn）患者的血红蛋白平均差异为-0.16 g/dL（95% CI -0.48，0.15；I 5%，p=0.39），无论疟疾类型和药物剂量如何。特别是在使用伯氨喹（PQ）时，剂量<0.5mg/kg/天的 G6PDd/G6PDn 患者的血红蛋白平均差异为-0.04（95% CI -0.35，0.27；I 0%，p=0.69）。G6PDd 患者发生贫血的风险比为 1.02（95% CI 0.75，1.38；I 0%，p=0.79）。
单次或每日标准剂量的 PQ（0.25mg/kg/天）和每周 PQ（0.75mg/kg/周）不会增加 G6PDd 患者发生贫血的风险。
