Maksimova N M, Sukhorukova N L, Kostiuchenko G I, Mikhaĭlova N B, Demina D I
Zh Mikrobiol Epidemiol Immunobiol. 1987 Aug(8):36-40.
The studies demonstrated the immunological and epidemiological effectiveness of a single injection of adsorbed diphtheria-tetanus toxoid with reduced antigen content for adults: intense antidiphtheria immunity in 92.3% of the vaccinees 1-3 months and in 94.5% of the vaccinees 1 year after the injection. This immunity remained sufficiently intense for 3 years (the term of observation). The geometric mean of antitoxic titers was 0.84 I. U./ml. The highest intensity of immunity appearing after the injection was observed in persons aged 18-20 years who showed the highest antitoxic titers (exceeding 0.5 I. U./ml) in 100% of cases, the lowest intensity was registered in the age group of 30-39 years; in 14.2% of these vaccinees antitoxic titers were below the protective level. In other age groups (40-49 years, 50 years and over) the intensity of immunity was high. The geometric mean of the titers of diphtheria antitoxin were 1.2 I. U./ml and 2.1 I. U./ml respectively. In none of the foci under study the spread of the manifest forms of the disease was observed.
这些研究证明了对成年人单次注射抗原含量降低的吸附白喉-破伤风类毒素的免疫和流行病学效果：注射后1至3个月，92.3%的接种者产生强烈的抗白喉免疫力；注射后1年，94.5%的接种者产生这种免疫力。这种免疫力在3年（观察期）内一直保持足够强。抗毒素效价的几何平均值为0.84国际单位/毫升。注射后出现的最高免疫强度在18至20岁的人群中观察到，这些人100%的病例中抗毒素效价最高（超过0.5国际单位/毫升），最低免疫强度记录在30至39岁年龄组；该年龄组14.2%的接种者抗毒素效价低于保护水平。在其他年龄组（40至49岁、50岁及以上）中，免疫强度较高。白喉抗毒素效价的几何平均值分别为1.2国际单位/毫升和2.1国际单位/毫升。在所研究的任何疫源地均未观察到该疾病显性形式的传播。
