从软珊瑚 Dendronephthya gigantea 中靶向 Keap1/Nrf2/ARE 信号通路的甾体型抗氧化剂。
A Steroid-Type Antioxidant Targeting the Keap1/Nrf2/ARE Signaling Pathway from the Soft Coral Dendronephthya gigantea.
机构信息
School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang 325035 , People's Republic of China.
Department of Pharmacy , The First People's Hospital of Yongkang , Yongkang , Zhejiang 321300 , People's Republic of China.
出版信息
J Nat Prod. 2018 Nov 26;81(11):2567-2575. doi: 10.1021/acs.jnatprod.8b00728. Epub 2018 Nov 8.
Four new steroids, named 7-dehydroerectasteroid F (1), 11α-acetoxyarmatinol A (2), 22,23-didehydroarmatinol A (3), and 3-O-acetylhyrtiosterol (4), together with 11 previously described analogues, were isolated from a South China Sea collection of the soft coral Dendronephthya gigantea. The structures of the new steroids were elucidated by comprehensive spectroscopic analysis and by comparison with previously reported data. Compound 1 showed potent protection against HO-induced oxidative damage in neuron-like PC12 cells by promoting nuclear translocation of Nrf2 and enhancing the expression of HO-1. 1 represents the first steroid-type antioxidant from marine organisms.
从南海软珊瑚 Dendronephthya gigantea 中分离得到了 4 种新甾体化合物，分别命名为 7-去氢 erectasteroid F（1）、11α-乙酰氧基 armatinol A（2）、22,23-去氢 armatinol A（3）和 3-O-乙酰基 hyrtiosterol（4），以及 11 种先前描述的类似物。新甾体化合物的结构通过综合光谱分析和与先前报道的数据进行比较来阐明。化合物 1 通过促进 Nrf2 的核转位和增强 HO-1 的表达，显示出对 HO 诱导的神经瘤样 PC12 细胞氧化损伤的有效保护作用。1 是第一种来自海洋生物的甾体类抗氧化剂。
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