Peng Puchao, Chen Lijie, Shen Qinjing, Xu Zhouming, Ding Xiufang
Puchao Peng, Department of Breast Surgery, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, P.R. China.
Lijie Chen, Department of Breast Surgery, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, P.R. China.
Pak J Med Sci. 2023 Sep-Oct;39(5):1535-1541. doi: 10.12669/pjms.39.5.7781.
To assess prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score could predict overall survival (OS) and disease-free survival (DFS) in patients with breast cancer.
PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar were searched from 1 January 2000 to 10 October 2021 for studies assessing the association between PNI or CONUT and outcomes of breast cancer by following the PRISMA guidelines. Keywords used were "Prognostic nutritional index", "Controlling nutritional status", "CONUT", and "Breast cancer".
Nine studies were included. On pooled analysis, we noted a statistically significant improved OS in patients with high PNI as compared to low PNI. Meta-analysis revealed no significant difference in DFS between patients with high PNI and low PNI. However, on the exclusion of one study, we noted that high PNI was associated with significantly improved DFS as compared to low PNI. On pooled analysis, we also noted that a high CONUT score was associated with significantly reduced OS in breast cancer patients.
Our results indicate that PNI is an important prognostic factor for patients with breast cancer. Pre-treatment low PNI is associated with worse OS and DFS. Scarce data also indicates that a high CONUT score is predictive of poor OS in breast cancer.
评估预后营养指数（PNI）和控制营养状况（CONUT）评分能否预测乳腺癌患者的总生存期（OS）和无病生存期（DFS）。
按照PRISMA指南，检索2000年1月1日至2021年10月10日期间的PubMed、Embase、ScienceDirect、CENTRAL和谷歌学术，以查找评估PNI或CONUT与乳腺癌预后之间关联的研究。使用的关键词为“预后营养指数”、“控制营养状况”、“CONUT”和“乳腺癌”。
纳入9项研究。汇总分析显示，与低PNI患者相比，高PNI患者的OS有统计学显著改善。荟萃分析显示，高PNI患者和低PNI患者的DFS无显著差异。然而，排除一项研究后，我们发现与低PNI相比，高PNI与显著改善的DFS相关。汇总分析还显示，高CONUT评分与乳腺癌患者的OS显著降低相关。
我们的结果表明，PNI是乳腺癌患者的重要预后因素。治疗前低PNI与较差的OS和DFS相关。有限的数据还表明，高CONUT评分预示着乳腺癌患者的OS较差。
