Zhang Qiang, Wang Chuanchi, Yang Yan, Xu Ruihan, Li Ziyun
Department of Digestive endoscopy, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Xin-Huangpu Joint Innovation Institute of Chinese Medicine, Guangzhou, Guangdong, China.
Front Cell Dev Biol. 2023 Feb 16;11:1052942. doi: 10.3389/fcell.2023.1052942. eCollection 2023.
Gastric cancer (GC) is a potential dominant disease in tumor immunotherapy checkpoint inhibitors, and adoptive cell therapy have brought great hope to GC patients. However, only some patients with GC can benefit from immunotherapy, and some patients develop drug resistance. More and more studies have shown that long non-coding RNAs (lncRNAs) may be important in GC immunotherapy's prognosis and drug resistance. Here, we summarize the differential expression of lncRNAs in GC and their impact on the curative effect of GC immunotherapy, discuss potential mechanisms of activity in GC immunotherapy resistance regulated by lncRNAs. This paper reviews the differential expression of lncRNA in GC and its effect on immunotherapy efficacy in GC. In terms of genomic stability, inhibitory immune checkpoint molecular expression, the cross-talk between lncRNA and immune-related characteristics of GC was summarized, including tumor mutation burden (TMB), microsatellite instability (MSI), and Programmed death 1 (PD-1). At the same time, this paper reviewed the mechanism of tumor-induced antigen presentation and upregulation of immunosuppressive factors, as well as the association between Fas system and lncRNA, immune microenvironment (TIME) and lncRNA, and summarized the functional role of lncRNA in tumor immune evasion and immunotherapy resistance.
胃癌（GC）是肿瘤免疫治疗检查点抑制剂潜在的主要治疗对象，过继性细胞疗法给GC患者带来了巨大希望。然而，只有部分GC患者能从免疫治疗中获益，部分患者会产生耐药性。越来越多的研究表明，长链非编码RNA（lncRNAs）可能在GC免疫治疗的预后和耐药性方面发挥重要作用。在此，我们总结了lncRNAs在GC中的差异表达及其对GC免疫治疗疗效的影响，探讨lncRNAs调控GC免疫治疗耐药性的潜在作用机制。本文综述了lncRNA在GC中的差异表达及其对GC免疫治疗疗效的影响。在基因组稳定性、抑制性免疫检查点分子表达方面，总结了lncRNA与GC免疫相关特征之间的相互作用，包括肿瘤突变负荷（TMB）、微卫星不稳定性（MSI）和程序性死亡1（PD-1）。同时，本文回顾了肿瘤诱导抗原呈递和免疫抑制因子上调的机制，以及Fas系统与lncRNA、免疫微环境（TIME）与lncRNA之间的关联，并总结了lncRNA在肿瘤免疫逃逸和免疫治疗耐药性中的功能作用。
