Zhang Xiaoli, Qu Qingli, Yang Anquan, Wang Jing, Cheng Weixia, Deng Yankang, Zhou Aying, Lu Tao, Xiong Ranhua, Huang Chaobo
Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, PR China.
Zhejiang OSM Group Co., Ltd, Huzhou 313000, PR China.
Carbohydr Polym. 2023 Jan 1;299:120134. doi: 10.1016/j.carbpol.2022.120134. Epub 2022 Sep 21.
The emergence, spread and difficult removal of bacteria biofilm, represent an ever-increasing persistent infections and medical complications challenge worldwide. Herein, a self-propelled system Prussian blue micromotor (PB MMs) were constructed by gas-shearing technology for efficient degradation of biofilms by combining chemodynamic therapy (CDT) and photothermal therapy (PTT). With the interpenetrating network crosslinked by alginate, chitosan (CS) and metal ions as the substrate, PB was generated and embedded in the micromotor at the same time of crosslinking. The micromotors are more stable and could capture bacteria with the addition of CS. The micromotors show excellent performance, containing photothermal conversion, reactive oxygen species (ROS) generation and bubble produced by catalyzing Fenton reaction for motion, which served as therapeutic agent could chemically kill bacteria and physically destroy biofilm. This research work opens a new path of an innovative strategy to efficiently remove biofilm.
细菌生物膜的出现、传播及难以清除，给全球范围内日益增加的持续性感染和医学并发症带来了挑战。在此，通过气剪技术构建了一种自驱动系统普鲁士蓝微马达（PB MMs），通过结合化学动力疗法（CDT）和光热疗法（PTT）来高效降解生物膜。以藻酸盐、壳聚糖（CS）和金属离子交联形成的互穿网络为底物，在交联的同时生成PB并将其嵌入微马达中。添加CS后，微马达更稳定且能够捕获细菌。微马达表现出优异的性能，包括光热转换、活性氧（ROS）生成以及通过催化芬顿反应产生气泡以实现运动，作为治疗剂，其可以化学杀灭细菌并物理破坏生物膜。这项研究工作为高效去除生物膜开辟了一条创新策略的新途径。
