Fernández-Landa Julen, Santibañez-Gutierrez Asier, Todorovic Nikola, Stajer Valdemar, Ostojic Sergej M
Physical Education and Sports Department, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), Vitoria, Spain.
Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia.
Sports Med. 2023 May;53(5):1017-1027. doi: 10.1007/s40279-023-01823-2. Epub 2023 Mar 6.
There is robust evidence that creatine monohydrate supplementation can enhance short-term high-intensity exercise in athletes. However, the effect of creatine monohydrate supplementation on aerobic performance and its role during aerobic activities is still controversial.
The purpose of this systematic review and meta-analysis was to evaluate the supplementation effects of creatine monohydrate on endurance performance in a trained population.
The search strategy in this systematic review and meta-analysis was designed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and PubMed/MEDLINE, Web of Science, and Scopus databases were explored from inception until 19 May, 2022. Only human experimental trials, controlled with a placebo group, evaluating the effects of creatine monohydrate supplementation on endurance performance in a trained population were analyzed in this systematic review and meta-analysis. The methodological quality of included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale.
A total of 13 studies satisfied all the eligibility criteria and were included in this systematic review and meta-analysis. The results for the pooled meta-analysis showed a non-significant change in endurance performance after creatine monohydrate supplementation in a trained population (p = 0.47), with a trivial negative effect (pooled standardized mean difference = - 0.07 [95% confidence interval - 0.32 to 0.18]; I = 34.75%). Further, after excluding the studies not evenly distributed around the base of the funnel plot, the results were similar (pooled standardized mean difference = - 0.07 [95% confidence interval - 0.27 to 0.13]; I = 0%; p = 0.49).
Creatine monohydrate supplementation was shown to be ineffective on endurance performance in a trained population.
The study protocol was registered in the Prospective Register of Systematic Review (PROSPERO) with the following registration number: CRD42022327368.
有充分证据表明，补充一水肌酸可增强运动员的短期高强度运动能力。然而，补充一水肌酸对有氧能力的影响及其在有氧运动中的作用仍存在争议。
本系统评价和荟萃分析的目的是评估补充一水肌酸对训练有素人群耐力表现的影响。
本系统评价和荟萃分析的检索策略是按照系统评价和荟萃分析的首选报告项目（PRISMA）指南设计的，对PubMed/MEDLINE、科学网和Scopus数据库从创建至2022年5月19日进行了检索。本系统评价和荟萃分析仅分析了有安慰剂组对照的人体实验性试验，这些试验评估了补充一水肌酸对训练有素人群耐力表现的影响。采用物理治疗证据数据库（PEDro）量表评估纳入研究的方法学质量。
共有13项研究符合所有纳入标准，被纳入本系统评价和荟萃分析。汇总荟萃分析结果显示，训练有素的人群补充一水肌酸后，耐力表现无显著变化（p = 0.47），有轻微负面影响（汇总标准化均差= -0.07 [95%置信区间 -0.32至0.18]；I = 34.75%）。此外，在排除漏斗图底部分布不均匀的研究后，结果相似（汇总标准化均差= -0.07 [95%置信区间 -0.27至0.13]；I = 0%；p = 0.49）。
补充一水肌酸对训练有素人群的耐力表现无效。
该研究方案已在系统评价前瞻性注册库（PROSPERO）注册，注册号如下：CRD42022327368。
