From the School of Life Science, Nantong Laboratory of Development and Diseases, Medical College; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Ann Plast Surg. 2023 Aug 1;91(2):313-318. doi: 10.1097/SAP.0000000000003480. Epub 2023 Mar 2.
Peripheral nerve injury is a common injury disease. Understanding of the mechanisms of periphery nerve repair and regeneration after injury is an essential prerequisite for treating related diseases. Although the biological mechanisms of peripheral nerve injury and regeneration have been studied comprehensively, the clinical treatment methods are still limited. The bottlenecks of the treatments are the shortage of donor nerves and the limited surgical precision. Apart from the knowledge regarding the fundamental characteristics and physical processes of peripheral nerve injury, numerous studies have found that Schwann cells, growth factors, and extracellular matrix are main factors affecting the repair and regeneration process of injured nerves. At present, the therapeutical methods of the disease include microsurgery, autologous nerve transplantation, allograft nerve transplantation and tissue engineering technology. Tissue engineering technology, which combines seed cells, neurotrophic factors, and scaffold materials together, is promising for treating the patients with long-gapped and large nerve damage. With the development of neuron science and technology, the treatment of peripheral nerve injury diseases will continue being improved.
周围神经损伤是一种常见的损伤性疾病。了解周围神经损伤后的修复和再生机制是治疗相关疾病的必要前提。尽管周围神经损伤和再生的生物学机制已经得到了全面研究，但临床治疗方法仍然有限。治疗的瓶颈是供体神经的短缺和有限的手术精度。除了对周围神经损伤的基本特征和物理过程的了解外，许多研究还发现施万细胞、生长因子和细胞外基质是影响损伤神经修复和再生过程的主要因素。目前，该疾病的治疗方法包括显微外科手术、自体神经移植、同种异体神经移植和组织工程技术。将种子细胞、神经营养因子和支架材料结合在一起的组织工程技术有望治疗长间隙和大神经损伤的患者。随着神经科学技术的发展，周围神经损伤疾病的治疗将不断得到改善。
