Isolation and Characterization of Anti-Mycobacterial Natural Products from a sp. Marine Sponge.

Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it is critical to develop antibiotic drugs that display novel mechanisms of action. Bioactivity-guided fractionation employing an Alamar blue assay for strain H37Rv led to the isolation of duryne () from a marine sponge sp. sampled in the Solomon Islands. Additionally, five new strongylophorine meroditerpene analogues (-) along with six known strongylophorines (-) were isolated from the bioactive fraction and characterized using MS and NMR spectroscopy, although only exhibited antitubercular activity.