Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
World J Gastroenterol. 2024 Sep 7;30(33):3799-3802. doi: 10.3748/wjg.v30.i33.3799.
The incidence rates of hepatocellular carcinoma (HCC) have increased in recent decades. Despite advancements in therapy and early diagnosis improving short-term prognosis, long-term outcomes remain poor. Long noncoding RNAs (lncRNAs) and lipid metabolism play crucial roles in the development and progression of HCC. Enhanced lipid synthesis promotes HCC progression, and lncRNAs can reprogram the expression of lipogenic enzymes. Consequently, lipid metabolism-related (LMR)-lncRNAs regulate lipid anabolism, accelerating the onset and progression of HCC. This suggests that LMR-lncRNAs could serve as novel prognostic biomarkers and therapeutic targets.
近年来，肝细胞癌（HCC）的发病率有所上升。尽管治疗和早期诊断方面的进展提高了短期预后，但长期结果仍然不佳。长链非编码 RNA（lncRNA）和脂质代谢在 HCC 的发生和发展中起着关键作用。增强的脂质合成促进 HCC 的进展，lncRNA 可以重新编程生脂酶的表达。因此，与脂质代谢相关的（LMR）-lncRNA 调节脂质合成，加速 HCC 的发生和发展。这表明 LMR-lncRNA 可以作为新的预后生物标志物和治疗靶点。
