Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, China.
Sci Rep. 2023 Mar 8;13(1):3889. doi: 10.1038/s41598-023-31112-x.
To investigate the relationship between metabolic syndrome (MS) and postoperative complications in Chinese adults after open pancreatic surgery. Relevant data were retrieved from the Medical system database of Changhai hospital (MDCH). All patients who underwent pancreatectomy from January 2017 to May 2019 were included, and relevant data were collected and analyzed. A propensity score matching (PSM) and a multivariate generalized estimating equation were used to investigate the association between MS and composite compositions during hospitalization. Cox regression model was employed for survival analysis. 1481 patients were finally eligible for this analysis. According to diagnostic criteria of Chinese MS, 235 patients were defined as MS, and the other 1246 patients were controls. After PSM, no association was found between MS and postoperative composite complications (OR: 0.958, 95%CI: 0.715-1.282, P = 0.958). But MS was associated with postoperative acute kidney injury (OR: 1.730, 95%CI: 1.050-2.849, P = 0.031). Postoperative AKI was associated with mortality in 30 and 90 days after surgery (P < 0.001). MS is not an independent risk factor correlated with postoperative composite complications after open pancreatic surgery. But MS is an independent risk factor for postoperative AKI of pancreatic surgery in Chinese population, and AKI is associated with survival after surgery.
探讨代谢综合征(MS)与中国成年人开腹胰腺手术后术后并发症的关系。从长海医院医疗系统数据库(MDCH)中检索到相关数据。纳入 2017 年 1 月至 2019 年 5 月接受胰腺切除术的所有患者,并收集和分析相关数据。采用倾向评分匹配(PSM)和多变量广义估计方程研究 MS 与住院期间复合成分之间的关系。采用 Cox 回归模型进行生存分析。最终有 1481 例患者符合本分析条件。根据中国 MS 的诊断标准,235 例患者被定义为 MS,其余 1246 例患者为对照组。PSM 后,MS 与术后复合并发症之间无关联(OR:0.958,95%CI:0.715-1.282,P=0.958)。但是,MS 与术后急性肾损伤(OR:1.730,95%CI:1.050-2.849,P=0.031)相关。术后 AKI 与术后 30 天和 90 天的死亡率相关(P<0.001)。MS 不是开腹胰腺手术后术后复合并发症的独立相关危险因素。但 MS 是中国人群胰腺手术后 AKI 的独立危险因素,AKI 与术后生存相关。