Englund E, Brun A
Department of Neuropathology, University Hospital, Lund, Sweden.
Arch Gerontol Geriatr. 1987 Sep;6(3):235-43. doi: 10.1016/0167-4943(87)90024-0.
The cerebral white matter in 16 cases of frontal lobe non-Alzheimer degeneration with dementia (FLD), four cases of Pick's disease and five age-matched controls was studied microscopically. All cases of dementia had white matter alterations, consisting of gliosis and loss of myelin, with a regional spread of changes that roughly corresponded with that of the cortical degeneration. The white matter changes were less severe than the cortical alterations, although the relative degree of severity between grey and white matter pathology varied from case to case. The white matter changes were in some respects similar in FLD and Pick's disease. They differed from those of other organic dementias. In FLD, they seem to be part of the histopathologic picture and to be secondary to the cortical degeneration.
对16例伴有痴呆的额叶非阿尔茨海默病性变性（FLD）、4例匹克病患者以及5例年龄匹配的对照者的脑白质进行了显微镜检查。所有痴呆病例均有白质改变，包括胶质增生和髓鞘脱失，其改变的区域分布大致与皮质变性区域分布相对应。白质改变比皮质改变轻，尽管灰质和白质病变的相对严重程度因病例而异。FLD和匹克病的白质改变在某些方面相似。它们与其他器质性痴呆的白质改变不同。在FLD中，白质改变似乎是组织病理学表现的一部分，继发于皮质变性。
