Wang Menglei, Lou Enzhe, Xue Zengfu
Department of Digestive Diseases, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Front Physiol. 2023 Feb 20;14:1115250. doi: 10.3389/fphys.2023.1115250. eCollection 2023.
A precancerous lesion of gastric cancer (GC), intestinal metaplasia (IM) is a pathological transformation of non-intestinal epithelium into an intestinal-like mucosa. It greatly raises the risk of developing the intestinal type of GC, which is frequently observed in the stomach and esophagus. It is understood that esophageal adenocarcinoma's precursor lesion, chronic gastroesophageal reflux disease (GERD), is what causes Barrett's esophagus (BE), an acquired condition. Recently, Bile acids (BAs), which are one of the compositions of gastric and duodenal contents, have been confirmed that it led to the occurrence and development of BE and gastric intestinal metaplasia (GIM). The objective of the current review is to discuss the mechanism of IM induced by bile acids. This review serves as a foundation for further research aimed at improving the way BE and GIM are currently managed.
胃癌（GC）的癌前病变——肠化生（IM），是指非肠上皮向肠样黏膜的病理转变。它极大地增加了发生肠型GC的风险，肠型GC在胃和食管中较为常见。据了解，食管腺癌的前驱病变——慢性胃食管反流病（GERD）会导致巴雷特食管（BE）这一后天性疾病。最近，胆汁酸（BAs）作为胃和十二指肠内容物的成分之一，已被证实可导致BE和胃肠化生（GIM）的发生与发展。本综述的目的是探讨胆汁酸诱导IM的机制。本综述为进一步研究改善目前BE和GIM的治疗方式奠定了基础。
