Wang Zhihuan, Song Liqiong, Li Xianping, Xiao Yuchun, Huang Yuanming, Zhang Yue, Li Jintong, Li Mingding, Ren Zhihong
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Research Units of Discovery of Unknown Bacteria and Function (2018 RU010), Chinese Academy of Medical Sciences, Beijing, China.
Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Nutr. 2023 Feb 20;10:1094483. doi: 10.3389/fnut.2023.1094483. eCollection 2023.
Hyperuricemia (HUA) is a common metabolic disease, and its prevalence has been increasing worldwide. Pharmaceutical drugs have been used for controlling HUA but they all have certain side effects, which thus calls for discovering alternative options including using treatment of probiotics to prevent the development of HUA.
We established HUA mice model induced by potassium oxonate and adenine and performed in vivo experiments to verify the ability to lower serum uric acid of P2020 (LPP), a probiotics stain extracted from Chinese pickle. We also tried to discussed the underlying mechanisms.
Oral administration with LPP significantly decreased serum uric acid and reduced renal inflammatory response by downregulating multiple inflammation pathways including NK-kB, MAPK, and TNFα. We also found that LPP administration significantly promoted uric acid excretion by regulating expression of transporters in the kidney and ileum. In addition, LPP intake improved intestinal barrier function and modulated the composition of gut microbiota.
These results suggest that probiotics LPP may have a promising potential to protect against development of HUA and HUA-related renal damage, and its working mechanisms involve regulation of inflammation pathways and expression of transporters in the kidney and ileum.
高尿酸血症（HUA）是一种常见的代谢性疾病，其在全球范围内的患病率一直在上升。药物已被用于控制高尿酸血症，但它们都有一定的副作用，因此需要寻找替代方案，包括使用益生菌治疗来预防高尿酸血症的发展。
我们建立了由氧嗪酸钾和腺嘌呤诱导的高尿酸血症小鼠模型，并进行体内实验，以验证从中国泡菜中提取的益生菌菌株P2020（LPP）降低血清尿酸的能力。我们还试图探讨其潜在机制。
口服LPP可显著降低血清尿酸，并通过下调包括NK-kB、MAPK和TNFα在内的多种炎症途径来减轻肾脏炎症反应。我们还发现，给予LPP可通过调节肾脏和回肠中转运蛋白的表达来显著促进尿酸排泄。此外，摄入LPP可改善肠道屏障功能并调节肠道微生物群的组成。
这些结果表明，益生菌LPP在预防高尿酸血症及其相关肾脏损伤方面可能具有广阔的潜力，其作用机制包括调节炎症途径以及肾脏和回肠中转运蛋白的表达。
