用于口腔医学的基于粘膜粘附电纺纤维的技术。

Edmans Jake G, Clitherow Katharina H, Murdoch Craig, Hatton Paul V, Spain Sebastian G, Colley Helen E

School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.

Department of Chemistry, Brook Hill, University of Sheffield, Sheffield S3 7HF, UK.

Pharmaceutics. 2020 Jun 2;12(6):504. doi: 10.3390/pharmaceutics12060504.

Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future.

口腔疾病极大地影响生活质量，因为口腔对于包括言语、进食和饮水在内的广泛活动至关重要。口腔疾病的治疗受到当前可用剂型的极大限制，这些剂型存在接触时间短、部位特异性差以及对机械刺激敏感等问题。使用静电纺丝制备的粘膜粘附装置有可能通过与粘膜紧密接触实现单向部位特异性药物递送，并具有高表面积以促进药物释放，从而应对这些挑战。本综述将讨论最近报道的用于治疗口腔炎症性疾病、缓解疼痛和感染的静电纺丝粘膜粘附装置的范围，以及该技术未来可能实现的新治疗方法。