J Refract Surg. 2023 Mar;39(3):158-164. doi: 10.3928/1081597X-20221221-03. Epub 2023 Mar 1.
To evaluate the accuracy of nine formulas to calculate the power of a new extended depth-of-focus intraocular lens (EDOF IOL), the AcrySof IQ Vivity (Alcon Laboratories, Inc), using measurements from two optical biometers, the IOLMaster 700 (Carl Zeiss Meditec AG) and Anterion (Heidelberg Engineering GmbH).
After constant optimization, the accuracy of these formulas was analyzed in 101 eyes: Barrett Universal II, EVO 2.0, Haigis, Hoffer Q, Holladay 1, Kane, Olsen, RBF 3.0, and SRK/T. Both standard and total keratometry from the IOLMaster 700 and standard keratometry from the Anterion were used for each formula.
Constant optimization provided slightly different values for the A-constant, which ranged between 118.99 and 119.16, depending on the formula and the optical biometer. According to the heteroscedastic test, within each keratometry modality the standard deviation of the SRK/T was significantly higher compared to that of the Holladay 1, Kane, Olsen, and RBF 3.0 formulas. The SRK/T formula provided less accurate results also when the absolute prediction errors were compared by Friedman test. According to McNemar's test with Holm corrections, statistically significant differences were found within each keratometry modality between the percentage of eyes with a prediction error within ±0.25 diopters obtained with the Olsen formula compared to the Holladay 1 and Hoffer Q formulas.
Constant optimization remains a mandatory step to achieve the best outcomes with the new EDOF IOL: the same constant should not be used for all formulas and for both optical biometers. Different statistical tests revealed that older IOL formulas have lower accuracy compared to newer formulas. .
评估 9 种公式计算新扩展景深人工晶状体（EDOF IOL），即 AcrySof IQ Vivity（Alcon Laboratories，Inc.）的准确性，使用两种光学生物测量仪，即 IOLMaster 700（Carl Zeiss Meditec AG）和 Anterion（Heidelberg Engineering GmbH）的测量值。
在经过恒定优化后，对 101 只眼的这些公式的准确性进行了分析：Barrett Universal II、EVO 2.0、Haigis、Hoffer Q、Holladay 1、Kane、Olsen、RBF 3.0 和 SRK/T。每个公式都使用 IOLMaster 700 的标准和总角膜曲率值和 Anterion 的标准角膜曲率值。
根据公式和光学生物测量仪的不同，A-常数的恒定优化值略有不同，范围在 118.99 到 119.16 之间。根据异方差检验，在每种角膜曲率模式下，SRK/T 公式的标准差明显高于 Holladay 1、Kane、Olsen 和 RBF 3.0 公式。通过 Friedman 检验比较绝对预测误差，SRK/T 公式的结果也不够准确。根据带有 Holm 校正的 McNemar 检验，在每种角膜曲率模式下，与 Holladay 1 和 Hoffer Q 公式相比，Olsen 公式获得的预测误差在±0.25 屈光度内的眼百分比在统计学上存在显著差异。
恒定优化仍然是使用新的 EDOF IOL 获得最佳结果的必要步骤：对于所有公式和两种光学生物测量仪，不应使用相同的常数。不同的统计检验表明，与较新的公式相比，旧的 IOL 公式的准确性较低。
