Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Medical Laboratory, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
PLoS One. 2023 Mar 9;18(3):e0279396. doi: 10.1371/journal.pone.0279396. eCollection 2023.
Helicobacter pylori is one of the most common bacterial infections of humankind that affects more than 50% of the world's population. It has been implicated as an important agent in the pathogenesis of peptic ulcer disease and gastric cancer. Data regarding its prevalence using stool antigen test is scarce in Ethiopia. Hence, the main aim of this study is to determine the prevalence of Helicobacter pylori infection among dyspeptic patients using stool antigen test and assessing the potential risk factors.
Institution based cross-sectional study was conducted on 373 dyspepsia patients. Data were collected using a pre-tested interviewer administered questionnaire. SPSS Version 23 for Windows software was used for summarization and analyses of data. Bivariate analysis was conducted to detect the association between dependent and independent variables, and all candidate variables were entered into multivariate logistic regression. Statistical significance was set at p-value <0.05.
More than one-third (34%) of dyspepsia patients were positive for H. pylori stool antigen test. Having greater than or equal to four children in the house [AOR = 7.5 95% CI (1.7, 33.6) p = 0.008)], absence of latrine for the house hold [AOR = 4.3 95% CI (1, 17.8), p = 0.043 and drinking of river water [AOR = 12.5 95% CI (1.5, 105), p = 0.021] were predictors of H-pylori infection.
More than one-third of dyspepsia patients were positive for H-pylori infection. Overcrowding and poor hygienic conditions are the main risk factors of H-pylori infection.
幽门螺杆菌是人类最常见的细菌感染之一，影响了世界上超过 50%的人口。它已被认为是消化性溃疡病和胃癌发病机制中的重要因素。关于其使用粪便抗原检测的流行率数据在埃塞俄比亚很少。因此，本研究的主要目的是使用粪便抗原检测确定消化不良患者中幽门螺杆菌感染的流行率，并评估潜在的危险因素。
在 373 例消化不良患者中进行了基于机构的横断面研究。使用经过预测试的访谈式问卷收集数据。使用 Windows 软件的 SPSS 版本 23 对数据进行总结和分析。进行了两变量分析以检测依赖变量和独立变量之间的关联，并且将所有候选变量都纳入多变量逻辑回归。统计显著性设定为 p 值<0.05。
超过三分之一（34%）的消化不良患者的 H. pylori 粪便抗原检测呈阳性。家中有多于或等于四个孩子[比值比（AOR）=7.5 95%置信区间（CI）（1.7，33.6）p=0.008]、家中没有厕所[AOR=4.3 95%CI（1，17.8），p=0.043]和饮用河水[AOR=12.5 95%CI（1.5，105），p=0.021]是 H. pylori 感染的预测因素。
超过三分之一的消化不良患者 H. pylori 感染呈阳性。人口拥挤和卫生条件差是 H. pylori 感染的主要危险因素。
