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Electrostatic Features for the Receptor Binding Domain of SARS-COV-2 Wildtype and Its Variants. Compass to the Severity of the Future Variants with the Charge-Rule.SARS-CoV-2 野生型及其变体受体结合域的静电特征。根据电荷规则预测未来变体的严重程度。
J Phys Chem B. 2022 Sep 15;126(36):6835-6852. doi: 10.1021/acs.jpcb.2c04225. Epub 2022 Sep 6.
2
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.N 端结构域环的进化重塑精细调节了 SARS-CoV-2 刺突。
EMBO Rep. 2022 Oct 6;23(10):e54322. doi: 10.15252/embr.202154322. Epub 2022 Sep 1.
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Peculiar Variations of the Electrostatic Potential of Spike Protein N-terminal Domain Associated with the Emergence of Successive SARS-CoV-2 Omicron Lineages.与新冠病毒奥密克戎变异株系列出现相关的刺突蛋白N端结构域静电势的特殊变化
J Infect. 2023 Jan;86(1):66-117. doi: 10.1016/j.jinf.2022.07.018. Epub 2022 Jul 29.
4
Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry.SARS-CoV-2 刺突蛋白中的域间通讯控制蛋白酶触发的细胞进入。
Cell Rep. 2022 May 3;39(5):110786. doi: 10.1016/j.celrep.2022.110786. Epub 2022 Apr 19.
5
The value of electrostatic potentials of the spike receptor binding and N-terminal domains in addressing transmissibility and infectivity of SARS-CoV-2 variants of concern.刺突受体结合域和N端结构域的静电势在解决新冠病毒变异株的传播性和感染性方面的价值。
J Infect. 2022 May;84(5):e62-e63. doi: 10.1016/j.jinf.2022.02.023. Epub 2022 Feb 23.
6
The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View.SARS-CoV-2 刺突糖蛋白直接结合外源性唾液酸：NMR 观察。
Angew Chem Int Ed Engl. 2022 Apr 25;61(18):e202201432. doi: 10.1002/anie.202201432. Epub 2022 Mar 7.
7
Prediction analysis of porcine AXL protein as a potential receptor for SARS-CoV-2.猪AXL蛋白作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）潜在受体的预测分析
J Infect. 2022 Apr;84(4):579-613. doi: 10.1016/j.jinf.2021.12.038. Epub 2021 Dec 30.
8
The electrostatic potential of the Omicron variant spike is higher than in Delta and Delta-plus variants: A hint to higher transmissibility?奥密克戎变异株刺突蛋白的静电势高于德尔塔和德尔塔plus变异株：这是其更高传播性的一个线索？
J Med Virol. 2022 Apr;94(4):1277-1280. doi: 10.1002/jmv.27528. Epub 2021 Dec 27.
9
Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.刺突蛋白中突变诱导的长程变构相互作用决定了新冠病毒变异株的传染性。
ACS Omega. 2021 Nov 10;6(46):31312-31327. doi: 10.1021/acsomega.1c05155. eCollection 2021 Nov 23.
10
Interaction Analysis on the SARS-CoV-2 Spike Protein Receptor Binding Domain Using Visualization of the Interfacial Electrostatic Complementarity.利用界面静电互补可视化对严重急性呼吸综合征冠状病毒2刺突蛋白受体结合域进行相互作用分析
J Phys Chem Lett. 2021 Nov 25;12(46):11267-11272. doi: 10.1021/acs.jpclett.1c02788. Epub 2021 Nov 12.

同一枚硬币的两面：新冠病毒刺突蛋白的N端结构域和受体结合结构域

Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike.

作者信息

Ciccozzi Massimo, Pascarella Stefano

机构信息

Medical Statistic & Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.

Department of Biochemical Sciences 'A Rossi Fanelli', Sapienza Università di Roma, Rome, 00185, Italy.

出版信息

Future Virol. 2023 Feb. doi: 10.2217/fvl-2022-0181. Epub 2023 Mar 6.

DOI:10.2217/fvl-2022-0181
PMID:36896145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9987531/
Abstract

The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.

摘要

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白受体结合域与N端结构域以一种复杂的机制相互作用。突变会调节刺突蛋白与宿主分子之间的相互作用。这篇社论评论了SARS-CoV-2刺突蛋白相互作用的复杂性。