ADIPOR1 和 ADIPOR2 的不同作用：泛癌症分析。
Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis.
机构信息
Central Laboratory of Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.
Department of Orthopedics of Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.
出版信息
Front Endocrinol (Lausanne). 2023 Feb 21;14:1119534. doi: 10.3389/fendo.2023.1119534. eCollection 2023.
INTRODUCTION
AdipoR1 and AdipoR2 proteins, encoded by ADIPOR1 and ADIPOR2 genes respectively, are the receptors of adiponectin secrected by adipose tissue. Increasing studies have identified the vital role of adipose tissue in various diseases, including cancers. Hence, there is an urgent need to explore the roles of AdipoR1 and AdipoR2 in cancers.
METHODS
We conducted a comprehensive pan-cancer analysis for the roles of AdipoR1 and AdipoR2 via several public databases, including expression differences, prognostic value, and the correlations with tumor microenvironment, epigenetic modification, and drug sensitivity.
RESULTS
Both ADIPOR1 and ADIPOR2 genes are dysregulated in most cancers, but their genomic alteration frequencies are low. In addition, they are also correlated with the prognosis of some cancers. Although they are not strongly correlated with tumor mutation burden (TMB) or microsatellite instability (MSI), ADIPOR1/2 genes display a significant association with cancer stemness, tumor immune microenvironment, immune checkpoint genes (especially CD274 and NRP1), and drug sensitivity.
DISCUSSION
ADIPOR1 and ADIPOR2 play critical roles in diverse cancers, and it is a potential strategy to treat tumors through targeting ADIPOR1 and ADIPOR2.
简介
脂肪因子受体 1（AdipoR1）和脂肪因子受体 2（AdipoR2）蛋白分别由 ADIPOR1 和 ADIPOR2 基因编码，是脂肪组织分泌的脂联素的受体。越来越多的研究表明，脂肪组织在包括癌症在内的各种疾病中起着至关重要的作用。因此，迫切需要探索 AdipoR1 和 AdipoR2 在癌症中的作用。
方法
我们通过包括表达差异、预后价值以及与肿瘤微环境、表观遗传修饰和药物敏感性的相关性在内的多个公共数据库，对 AdipoR1 和 AdipoR2 在癌症中的作用进行了全面的泛癌症分析。
结果
ADIPOR1 和 ADIPOR2 基因在大多数癌症中都失调，但它们的基因组改变频率较低。此外，它们与一些癌症的预后也相关。尽管它们与肿瘤突变负担（TMB）或微卫星不稳定性（MSI）没有强烈相关性，但 ADIPOR1/2 基因与癌症干性、肿瘤免疫微环境、免疫检查点基因（尤其是 CD274 和 NRP1）以及药物敏感性显著相关。
讨论
AdipoR1 和 AdipoR2 在多种癌症中发挥着关键作用，通过靶向 AdipoR1 和 AdipoR2 治疗肿瘤可能是一种潜在的策略。
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