硝苯地平的经肝提取率。
The trans-hepatic extraction of nifedipine.
作者信息
Challenor V F, Waller D G, Renwick A G, Gruchy B S, George C F
机构信息
Clinical Pharmacology Group, University of Southampton.
出版信息
Br J Clin Pharmacol. 1987 Oct;24(4):473-7. doi: 10.1111/j.1365-2125.1987.tb03200.x.
Abstract
- The trans-hepatic extraction of nifedipine during steady state infusion was studied in six patients undergoing cardiac catheterisation for suspected coronary disease. 2. Mean extraction ratio across the liver was 0.64 but hepatic clearance accounted for a mean of only 65% of total body clearance. 3. These results are consistent with the liver as the major site of metabolism of nifedipine, but also suggest that significant metabolism occurs outside the liver.
摘要
- 在6名因疑似冠心病接受心导管检查的患者中，研究了稳态输注期间硝苯地平的经肝提取情况。2. 肝脏的平均提取率为0.64，但肝清除率平均仅占全身清除率的65%。3. 这些结果与硝苯地平以肝脏为主要代谢部位一致，但也表明肝脏外存在显著的代谢。
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