硝苯地平对运动诱发性哮喘的抑制作用：一项剂量反应研究。
Inhibition of exercise-induced asthma by nifedipine: a dose-response study.
作者信息
Rafferty P, Varley J G, Edwards J S, Holgate S T
机构信息
Medicine 1, Centre Block, Southampton General Hospital, Hampshire.
出版信息
Br J Clin Pharmacol. 1987 Oct;24(4):479-84. doi: 10.1111/j.1365-2125.1987.tb03201.x.
Abstract
- The effect of three single doses of nifedipine on exercise-induced asthma has been examined in 11 asthmatic subjects. 2. On four separate days patients undertook 6 min of exercise on a treadmill 30 min after taking placebo or nifedipine 10, 20 or 30 mg administered double-blind and in random order. 3. Nifedipine had no significant effect on resting FEV1 measurements. 4. Nifedipine, in doses of 10, 20 and 30 mg, inhibited exercise induced bronchoconstriction, reducing the maximum fall in FEV1 from 30.8 +/- 3.5% after placebo to 21.9 +/- 3.4% (NS), 13 +/- 3.4% (P less than 0.01) and 15 +/- 3.9% (P less than 0.01) respectively. 5. This study has shown that the protective effect of nifedipine against exercise-induced asthma is dose related with the maximum inhibitory effect being observed with a single dose of 20 mg.
摘要
- 已在11名哮喘患者中研究了单次服用3种剂量硝苯地平对运动诱发性哮喘的影响。2. 在4个不同日期，患者在服用安慰剂或10毫克、20毫克或30毫克硝苯地平后30分钟，以双盲随机顺序在跑步机上进行6分钟运动。3. 硝苯地平对静息第一秒用力呼气量（FEV1）测量无显著影响。4. 10毫克、20毫克和30毫克剂量的硝苯地平可抑制运动诱发的支气管收缩，使FEV1的最大下降幅度分别从服用安慰剂后的30.8±3.5%降至21.9±3.4%（无统计学意义）、13±3.4%（P<0.01）和15±3.9%（P<0.01）。5. 本研究表明，硝苯地平对运动诱发性哮喘的保护作用与剂量相关，单次服用20毫克时观察到最大抑制效果。
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