原发性乳腺癌预后指数的验证。
Confirmation of a prognostic index in primary breast cancer.
作者信息
Todd J H, Dowle C, Williams M R, Elston C W, Ellis I O, Hinton C P, Blamey R W, Haybittle J L
机构信息
City Hospital, Nottingham, UK.
出版信息
Br J Cancer. 1987 Oct;56(4):489-92. doi: 10.1038/bjc.1987.230.
Abstract
A prognostic index, previously derived in a group of 387 patients with primary breast cancer, has been recalculated for the same patients with over 5 years further follow-up and shown to be unchanged. The prognostic index has also been applied prospectively to a further group of 320 patients and shown to be similarly effective in identifying patients with either a very good or a very poor prognosis. It has been verified that the index applies to patients with primary breast cancer. Patients have now been divided into 5 prognostic groups, predicting 11% of patients with an almost normal survival and a further 10% with a very poor prognosis. The index is used to stratify patients to study the effects of treatment regimes within groups of similar patients.
摘要
之前在一组387例原发性乳腺癌患者中得出的一个预后指数，在对同一组患者进行了5年以上的进一步随访后重新计算，结果显示该指数没有变化。该预后指数还前瞻性地应用于另一组320例患者，结果表明在识别预后非常好或非常差的患者方面同样有效。现已证实该指数适用于原发性乳腺癌患者。患者现在已被分为5个预后组，预计11%的患者生存期几乎正常，另有10%的患者预后非常差。该指数用于对患者进行分层，以研究相似患者组内治疗方案的效果。
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