Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, P. R. China.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, 637371, Singapore.
Angew Chem Int Ed Engl. 2023 May 2;62(19):e202217995. doi: 10.1002/anie.202217995. Epub 2023 Mar 31.
Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single-atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile "missing-linker-confined coordination" strategy to fabricate two self-assembled nanozymes, i.e., conventional nanozyme (NE) and single-atomic nanozyme (SAE), which respectively consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, thus exhibiting a more efficient reactive oxygen species generation and high tumor inhibition rate.
传统纳米酶通常具有较低的活性位密度。寻求构建具有最高原子利用率的高效单原子纳米系统的有效策略是非常有吸引力的。在此，我们开发了一种简便的“缺失配体限制配位”策略，制备了两种自组装纳米酶，即常规纳米酶（NE）和单原子纳米酶（SAE），它们分别由 Pt 纳米颗粒和单 Pt 原子作为活性催化位点锚定在金属有机骨架（MOFs）中，封装了光敏剂，以模拟过氧化物酶的增强光动力治疗。与基于 Pt 纳米颗粒的常规纳米酶相比，Pt 单原子纳米酶在生成氧气以克服肿瘤缺氧方面表现出增强的过氧化物酶模拟活性，从而产生更高效率的活性氧物种生成和更高的肿瘤抑制率。
