State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
University of Chinese Academy of Sciences , Beijing 100039, P. R. China.
ACS Nano. 2018 Jan 23;12(1):651-661. doi: 10.1021/acsnano.7b07746. Epub 2018 Jan 5.
Metal-organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by converting tumor oxygen into reactive singlet oxygen (O). However, the PDT efficiency of MOFs is severely limited by tumor hypoxia. Herein, by decorating platinum nanozymes on photosensitizer integrated MOFs, we report a simple yet versatile strategy for enhanced PDT. The platinum nanoparticles homogeneously immobilized on MOFs possess high stability and catalase-like activity. Thus, our nanoplatform can facilitate the formation of O in hypoxic tumor site via HO-activated evolvement of O, which can cause more serious damage to cancer cells. Our finding highlights that the composites of nanozymes and MOFs have the potential to serve as efficient agents for cancer therapy, which will open an avenue of nanozymes and MOFs toward biological applications.
金属-有机框架（MOFs）已被用于癌症的光动力疗法（PDT），方法是将光敏剂整合在一起，通过将肿瘤氧气转化为活性单线态氧（O）对癌细胞产生细胞毒性作用。然而，MOFs 的 PDT 效率受到肿瘤缺氧的严重限制。在此，通过在整合了光敏剂的 MOFs 上修饰铂纳米酶，我们报告了一种用于增强 PDT 的简单而通用的策略。均匀固定在 MOFs 上的铂纳米颗粒具有高稳定性和类过氧化物酶活性。因此，我们的纳米平台可以通过 HO 激活的 O 的演变促进缺氧肿瘤部位 O 的形成，从而对癌细胞造成更严重的损害。我们的发现强调了纳米酶和 MOFs 的复合材料有可能成为癌症治疗的有效药物，这将为纳米酶和 MOFs 开辟一条通往生物应用的途径。
